دورية أكاديمية
Levetiracetam in a broad population of patients with refractory epilepsy: interim results of the international SKATE trial
| العنوان: | Levetiracetam in a broad population of patients with refractory epilepsy: interim results of the international SKATE trial |
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| المؤلفون: | Genton, P, Sadzot, B, Fejerman, N, Peltola, J, Despland, P-A, Steinhoff, B, Rektor, I, Wroe, S, Maubrey, M-C, Vandervelden, C, van Hammée, G, Schlit, A-F, Van Paesschen, Wim |
| بيانات النشر: | Munksgaard |
| سنة النشر: | 2006 |
| المجموعة: | KU Leuven: Lirias |
| مصطلحات موضوعية: | Adult, Anticonvulsants, Disorders of Excessive Somnolence, Dizziness, Dose-Response Relationship, Drug, Drug Resistance, Epilepsy, Female, Headache, Humans, International Cooperation, Male, Middle Aged, Piracetam, Prospective Studies, Sensation Disorders, Treatment Outcome |
| الوصف: | OBJECTIVE: To prospectively assess the safety and efficacy of levetiracetam in patients with uncontrolled focal epilepsy, in a common practice-based setting. PATIENTS AND METHODS: In this phase IV, open-label, 16-week community-based study, adult patients with focal seizures initially received levetiracetam 1,000 mg/day. Throughout the study, the dose was adjusted in increments of 1,000 mg (maximum 3,000 mg/day) to achieve seizure control and maintain tolerability. The outcome parameters were the percentage reduction in partial and total seizure frequency per week from historical baseline, global evaluation scale (GES), and adverse events (AE). RESULTS: Seven hundred and thirty-one patients were included in this analysis and 84.4% completed the study. The median percent reduction in all seizures was 47.8%, and 49.3% for all partial seizures. The 50% responder rate was 49%, and the seizure-free rate was 17.2% for all partial seizures. Approximately 60% of patients showed moderate to marked improvement on the GES. The majority of AE were of mild to moderate severity; the most commonly reported being asthenia, somnolence, headache, and dizziness. CONCLUSION: Levetiracetam is both efficacious and safe as an add-on therapy in patients with refractory epilepsy treated by clinicians in their daily practice. ; status: published |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0001-6314 |
| العلاقة: | Acta Neurologica Scandinavica vol:113 issue:6 pages:387-394; https://lirias.kuleuven.be/handle/123456789/17997Test; http://onlinelibrary.wiley.com/openurl?genre=article&sid=nlm:pubmed&issn=0001-6314&date=2006&volume=113&issue=6&spage=387Test; https://lirias.kuleuven.be/bitstream/123456789/17997/1//2006+Genton+SKATE.pdfTest |
| الإتاحة: | https://lirias.kuleuven.be/handle/123456789/17997Test http://onlinelibrary.wiley.com/openurl?genre=article&sid=nlm:pubmed&issn=0001-6314&date=2006&volume=113&issue=6&spage=387Test https://lirias.kuleuven.be/bitstream/123456789/17997/1//2006+Genton+SKATE.pdfTest |
| رقم الانضمام: | edsbas.E1DCEECA |
| قاعدة البيانات: | BASE |
| تدمد: | 00016314 |
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