Clinical and Molecular-Genetic Insights into the Role of Oxidative Stress in Diabetic Retinopathy: Antioxidant Strategies and Future Avenues
| العنوان: | Clinical and Molecular-Genetic Insights into the Role of Oxidative Stress in Diabetic Retinopathy: Antioxidant Strategies and Future Avenues |
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| المؤلفون: | Sanz-González SM, García-Medina JJ, Zanón-Moreno V, López-Gálvez MI, Galarreta-Mira D, Duarte L, Valero-Velló M, Ramírez AI, Arévalo JF, Pinazo-Durán MD, On Behalf Of The Valencia Study Group On Diabetic Retinopathy Vsdr Report Number |
| المصدر: | Antioxidants r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-FISABIO. Repositorio Institucional de Producción Científica INIA: Repositorio de Resultados de Investigación del INIA |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute (MDPI), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | antioxidants, omega-3 fatty acids, prevention of blindness, type 2 diabetes mellitus, retinopathy, candidate biomarkers, oxidative stress |
| الوصف: | Reactive oxygen species (ROS) overproduction and ROS-signaling pathways activation attack the eyes. We evaluated the oxidative stress (OS) and the effects of a daily, core nutritional supplement regimen containing antioxidants and omega 3 fatty acids (A/omega 3) in type 2 diabetics (T2DM). A case-control study was carried out in 480 participants [287 T2DM patients with (+)/without (-) diabetic retinopathy (DR) and 193 healthy controls (CG)], randomly assigned to a daily pill of A/omega 3. Periodic evaluation through 38 months allowed to outline patient characteristics, DR features, and classic/OS blood parameters. Statistics were performed by the SPSS 24.0 program. Diabetics displayed significantly higher circulating pro-oxidants (p = 0.001) and lower antioxidants (p = 0.0001) than the controls. Significantly higher plasma malondialdehyde/thiobarbituric acid reactive substances (MDA/TBARS; p = 0.006) and lower plasma total antioxidant capacity (TAC; p = 0.042) and vitamin C (0.020) was found in T2DM + DR versus T2DM-DR. The differential expression profile of solute carrier family 23 member 2 (SLC23A2) gene was seen in diabetics versus the CG (p = 0.001), and in T2DM + DR versus T2DM - DR (p < 0.05). The A/omega 3 regime significantly reduced the pro-oxidants (p < 0.05) and augmented the antioxidants (p < 0.05). This follow-up study supports that a regular A/omega 3 supplementation reduces the oxidative load and may serve as a dietary prophylaxis/adjunctive intervention for patients at risk of diabetic blindness. |
| تدمد: | 2076-3921 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4c5a5d2573bfabd2e417aab3b44e5895Test https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=8307Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.dedup.wf.001..4c5a5d2573bfabd2e417aab3b44e5895 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763921 |
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