Prenatal Exposure to Perfluoroalkyl Substances and Behavioral Development in Children
| العنوان: | Prenatal Exposure to Perfluoroalkyl Substances and Behavioral Development in Children |
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| المؤلفون: | Marijke de Cock, Michiel R. de Boer, Marja H. Lamoree, Ilona Quaak, Margot van de Bor, Pim E.G. Leonards |
| المساهمون: | Health & Life, Chemistry and Biology, Amsterdam Global Change Institute |
| المصدر: | Quaak, I, de Cock, M, Boer, M, Lamoree, M H, Leonards, P E G & van de Bor, M 2016, ' Prenatal Exposure to Perfluoroalkyl Substances and Behavioral Development in Children ', International Journal of Environmental Research and Public Health, vol. 13, no. 5, pp. 1-20 . https://doi.org/10.3390/ijerph13050511Test International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health; Volume 13; Issue 5; Pages: 511 International Journal of Environmental Research and Public Health, Vol 13, Iss 5, p 511 (2016) International Journal of Environmental Research and Public Health, 13(5), 1-20. Multidisciplinary Digital Publishing Institute (MDPI) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute (MDPI), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Perfluorooctanesulfonic acid, Attention Deficit Hyperactivity Disorder, Health, Toxicology and Mutagenesis, lcsh:Medicine, CBCL, prenatal exposure, 010501 environmental sciences, perfluoroalkyl substances, endocrine disrupting chemicals, behavioral development, early life exposure, preschool children, 01 natural sciences, Developmental psychology, chemistry.chemical_compound, Pregnancy, Surveys and Questionnaires, Family history, Child Behavior Checklist, Netherlands, education.field_of_study, Fluorocarbons, Fetal Blood, Checklist, Alkanesulfonic Acids, Child, Preschool, Prenatal Exposure Delayed Effects, Cohort, Female, Psychology, Adult, Population, Endocrine System, Child Behavior Disorders, Article, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Environmental health, medicine, Attention deficit hyperactivity disorder, Humans, education, 0105 earth and related environmental sciences, lcsh:R, Public Health, Environmental and Occupational Health, Infant, medicine.disease, 030104 developmental biology, chemistry |
| الوصف: | Background: In recent years, prevalence rates of behavioral disorders in children have increased. One factor possibly implied in the etiology of behavioral disorders is exposure to perfluoroalkyl substances (PFASs). The use of PFASs is highly integrated into everyday life, and exposure is ubiquitous. Exposure to PFASs during early life may be particularly harmful, as it represents a critical time window for brain development. However, research in the area is limited, especially among preschool children. The objective of the current study was to explore the relationship between prenatal exposure to several PFASs and behavioral development at the age of 18 months. Methods: Data from the Dutch cohort LINC (Linking Maternal Nutrition to Child Health) were used. Perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) were measured in cord plasma. The total exposure of PFASs was also calculated (SPFASs). Behavioral development was assessed with the Child Behavior Checklist 1.5–5 (CBCL 1.5–5). The CBCL scales “Attention Deficit Hyperactivity Disorder” (ADHD) and “Externalizing problems” were used for further analysis. Separate regression models were composed for each combination, in which exposure levels were classified in tertiles. Both whole population and sex-stratified analyses were performed. A family history of ADHD, the educational level, smoking or using alcohol or illicit drugs during pregnancy were considered as confounders. In total, data from 76 mother-child pairs was included. Results: No significant associations were found between prenatal PFAS exposure and ADHD scores in the whole population and in the sex-stratified analyses. With regard to externalizing behavior, a significant negative association was found between the highest levels of SPFAS exposure and externalizing problem behavior in the whole population, but only in the crude model. After stratifying for sex, boys in the second and third tertile of exposure to PFOA presented significantly lower scores on the Externalizing Problem Scale than boys with the lowest exposure levels in the adjusted model. Girls exposed to higher levels of ΣPFAS exposure (T2) showed significantly lower scores on the Externalizing Problem Scale, in both crude and adjusted models. No significant associations with PFOS were found. Conclusions: Results from the current study show that prenatal exposure to PFOA was negatively related to externalizing behavior in boys. Results were different for boys and girls, emphasizing that mechanisms at work might be sex-dependent. However, results should be interpreted with caution as the sample size was small. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1660-4601 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3923a8c91c87a50255866882e75efeTest https://doi.org/10.3390/ijerph13050511Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dc3923a8c91c87a50255866882e75efe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16604601 |
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