التفاصيل البيبلوغرافية
| العنوان: |
Anti-Inflammatory Effect of Methylpenicinoline from a Marine Isolate of Penicillium sp. (SF-5995): Inhibition of NF-κB and MAPK Pathways in Lipopolysaccharide-Induced RAW264.7 Macrophages and BV2 Microglia |
| المؤلفون: |
Dong-Cheol Kim, Hee-Suk Lee, Wonmin Ko, Dong-Sung Lee, Jae Sohn, Joung Yim, Youn-Chul Kim, Hyuncheol Oh |
| المصدر: |
Molecules; Volume 19; Issue 11; Pages: 18073-18089 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2014 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
methylpenicinoline, Penicillium sp., marine fungus, anti-inflammation, nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase (MAPK) |
| جغرافية الموضوع: |
agris |
| الوصف: |
In the course of a search for anti-inflammatory metabolites from marine-derived fungi, methylpenicinoline (1) was isolated from a marine isolate of Penicillin sp. Compound 1 inhibited lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production by suppressing the expression of inducible NO synthase (iNOS) in RAW264.7 macrophages and BV2 microglia. It also attenuated prostaglandin E2 (PGE2) production by suppressing cyclooxygenase-2 (COX-2) expression in a concentration-dependent manner (from 10 μM to 80 μM) without affecting cell viability. In addition, compound 1 reduced the production of the pro-inflammatory cytokine interleukin-1β (IL-1β). In a further study designed to elucidate the mechanism of its anti-inflammatory effects, compound 1 was shown to block nuclear factor-kappa B (NF-κB) activation in LPS-induced RAW264.7 macrophages and BV2 microglia by inhibiting the phosphorylation of inhibitor kappa B-α (IκB-α), thereby suppressing the nuclear translocation of NF-κB dimers, namely p50 and p65, that are known to be crucial molecules associated with iNOS and COX-2 expression. In addition, compound 1 inhibited the activation of mitogen-activated protein kinase (MAPK) pathways. Taken together, the results suggest that compound 1 might be a valuable therapeutic agent for the treatment of anti-inflammatory and anti-neuroinflammatory diseases. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Natural Products Chemistry; https://dx.doi.org/10.3390/molecules191118073Test |
| DOI: |
10.3390/molecules191118073 |
| الإتاحة: |
https://doi.org/10.3390/molecules191118073Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.F8E7897C |
| قاعدة البيانات: |
BASE |
