التفاصيل البيبلوغرافية
| العنوان: |
The Effect of Exercise Training on Myocardial and Skeletal Muscle Metabolism by MR Spectroscopy in Rats with Heart Failure |
| المؤلفون: |
Mingshu Shi, Øyvind Ellingsen, Tone Frost Bathen, Morten A. Høydal, Tomas Stølen, Morteza Esmaeili |
| المصدر: |
Metabolites; Volume 9; Issue 3; Pages: 53 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2019 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
metabolomics, MRS, magnetic resonance spectroscopy, cardiac metabolism |
| الوصف: |
The metabolism and performance of myocardial and skeletal muscle are impaired in heart failure (HF) patients. Exercise training improves the performance and benefits the quality of life in HF patients. The purpose of the present study was to determine the metabolic profiles in myocardial and skeletal muscle in HF and exercise training using MRS, and thus to identify targets for clinical MRS in vivo. After surgically establishing HF in rats, we randomized the rats to exercise training programs of different intensities. After the final training session, rats were sacrificed and tissues from the myocardial and skeletal muscle were extracted. Magnetic resonance spectra were acquired from these extracts, and principal component and metabolic enrichment analysis were used to assess the differences in metabolic profiles. The results indicated that HF affected myocardial metabolism by changing multiple metabolites, whereas it had a limited effect on skeletal muscle metabolism. Moreover, exercise training mainly altered the metabolite distribution in skeletal muscle, indicating regulation of metabolic pathways of taurine and hypotaurine metabolism and carnitine synthesis. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Frontiers in Metabolomics; https://dx.doi.org/10.3390/metabo9030053Test |
| DOI: |
10.3390/metabo9030053 |
| الإتاحة: |
https://doi.org/10.3390/metabo9030053Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.283ED303 |
| قاعدة البيانات: |
BASE |
