Functional State of Rat Heart Mitochondria in Experimental Hyperthyroidism
| العنوان: | Functional State of Rat Heart Mitochondria in Experimental Hyperthyroidism |
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| المؤلفون: | Vlada S. Starinets, Anna B. Nikiforova, Natalya I. Venediktova, Galina D. Mironova, Ilya Solomadin |
| المصدر: | International Journal of Molecular Sciences Volume 22 Issue 21 International Journal of Molecular Sciences, Vol 22, Iss 11744, p 11744 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, QH301-705.5, Respiratory chain, Mitochondrion, medicine.disease_cause, Hyperthyroidism, Catalysis, Mitochondria, Heart, Article, respiratory complexes, Inorganic Chemistry, Lipid peroxidation, Superoxide dismutase, chemistry.chemical_compound, Oxygen Consumption, Internal medicine, energy metabolism, mitochondrial dysfunction, medicine, Animals, oxidative stress, Physical and Theoretical Chemistry, Biology (General), Rats, Wistar, Molecular Biology, QD1-999, Spectroscopy, Palmitoylcarnitine, chemistry.chemical_classification, thyroid hormones, biology, Glutathione peroxidase, Organic Chemistry, General Medicine, Glutathione, Computer Science Applications, Rats, mitochondria, Chemistry, Disease Models, Animal, Thyroxine, Endocrinology, chemistry, biology.protein, Triiodothyronine, Lipid Peroxidation, Oxidative stress |
| الوصف: | In this work, the effect of thyroxine on energy and oxidative metabolism in the mitochondria of the rat heart was studied. Hyperthyroidism was observed in experimental animals after chronic administration of T4, which was accompanied by an increase in serum concentrations of free triiodothyronine (T3) and thyroxine (T4) by 1.8 and 3.4 times, respectively. The hyperthyroid rats (HR) had hypertrophy of the heart. In HR, there was a change in the oxygen consumption in the mitochondria of the heart, especially when using palmitoylcarnitine. The assay of respiratory chain enzymes revealed that the activities of complexes I, I + III, III, IV increased, whereas the activities of complexes II, II + III decreased in heart mitochondria of the experimental animals. It was shown that the level of respiratory complexes of the electron transport chain in hyperthyroid rats increased, except for complex V, the quantity of which was reduced. The development of oxidative stress in HR was observed: an increase in the hydrogen peroxide production rate, increase in lipid peroxidation and reduced glutathione. The activity of superoxide dismutase in the heart of HR was higher than in the control. At the same time, the activity of glutathione peroxidase decreased. The obtained data indicate that increased concentrations of thyroid hormones lead to changes in energy metabolism and the development of oxidative stress in the heart of rats, which in turn contributes to heart dysfunction. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| DOI: | 10.3390/ijms222111744 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e62513c94bc3a23f9ae22c24159b02Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....97e62513c94bc3a23f9ae22c24159b02 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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| DOI: | 10.3390/ijms222111744 |