التفاصيل البيبلوغرافية
| العنوان: |
Six-Month Synbio® Administration Affects Nutritional and Inflammatory Parameters of Older Adults Included in the PROBIOSENIOR Project |
| المؤلفون: |
Chiara Salvesi, Stefania Silvi, Dennis Fiorini, Laura Alessandroni, Gianni Sagratini, Francesco Alessandro Palermo, Renato De Leone, Nadaniela Egidi, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura, Amedeo Amedei, Elena Niccolai, Francesca Scocchera, Fausto Mannucci, Valerio Valeriani, Marco Malavasi, Sara Servili, Andrea Casula, Andrea Cresci, Ivano Corradetti, Maria Magdalena Coman, M. Cristina Verdenelli |
| المصدر: |
Microorganisms; Volume 11; Issue 3; Pages: 801 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
probiotics, malnutrition, inflammation, elderly |
| جغرافية الموضوع: |
agris |
| الوصف: |
The physiological changes associated with ageing contribute to the incidence of diseases, morbidity, and mortality. For modern society, it is essential to find solutions to improve elderly people’s health and quality of life. Among promising strategies, the PROBIOSENIOR project proposed a daily six-month supplementation with new probiotic functional foods and nutraceuticals. The aim of this work was to evaluate the modulating effects of the probiotic diet on inflammatory markers and nutritional status. Ninety-seven elderly volunteers were randomly assigned to either a placebo-diet group or a probiotic-diet group (SYNBIO®). Faeces, urine, and blood samples were collected before and after the supplementation to determine serum cytokines, biogenic amines, and inflammation markers. Comparing the results obtained before and after the intervention, probiotic supplementations significantly decreased the TNF-α circulating levels and significantly increased those of IGF-1. Biogenic-amine levels showed high variability, with significant variation only for histamine that decreased after the probiotic supplementation. The supplementation influenced the serum concentration of some crucial cytokines (IL-6, IL-8, and MIP-1α) that significantly decreased in the probiotic group. In addition, the Mini Nutritional Assessment questionnaire revealed that the probiotic-supplemented group had a significant improvement in nutritional status. In conclusion, the PROBIOSENIOR project demonstrated how SYNBIO® supplementation may positively influence some nutritional and inflammatory parameters in the elderly. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Food Microbiology; https://dx.doi.org/10.3390/microorganisms11030801Test |
| DOI: |
10.3390/microorganisms11030801 |
| الإتاحة: |
https://doi.org/10.3390/microorganisms11030801Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.79030E85 |
| قاعدة البيانات: |
BASE |
