التفاصيل البيبلوغرافية
| العنوان: |
A Review of Approaches to the Metallic and Non-Metallic Synthesis of Benzimidazole (BnZ) and Their Derivatives for Biological Efficacy |
| المؤلفون: |
Muhammad Patel, Gopal Avashthi, Amel Gacem, Mohammed S. Alqahtani, Hyun-Kyung Park, Byong-Hun Jeon |
| المصدر: |
Molecules; Volume 28; Issue 14; Pages: 5490 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
benzimidazole, heterocyclic derivatives, biological activity |
| جغرافية الموضوع: |
agris |
| الوصف: |
Heterocyclic compounds are significant lead drug candidates based on their various structure–activity relationships (SAR), and their use in pharmaceutics is constantly developing. Benzimidazole (BnZ) is synthesized by a condensation reaction between benzene and imidazole. The BnZ structure consists of two nitrogen atoms embedded in a five-membered imide ring which is fused with a benzene ring. This review examines the conventional and green synthesis of metallic and non-metallic BnZ and their derivatives, which have several potential SARs, along with a wide range of pharmacological properties, including anti-cancer, anti-inflammatory, anti-microbial, anti-tubercular, and anti-protozoal properties. These compounds have been proven by pharmacological investigations to be efficient against different strains of microbes. Therefore, in this review, the structural variations of BnZ are listed along with various applications, predominantly related to their biological activities. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Organic Chemistry; https://dx.doi.org/10.3390/molecules28145490Test |
| DOI: |
10.3390/molecules28145490 |
| الإتاحة: |
https://doi.org/10.3390/molecules28145490Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.4592AF33 |
| قاعدة البيانات: |
BASE |
