Gut Microbiota Dysbiosis Is Associated with Elevated Bile Acids in Parkinson’s Disease
| العنوان: | Gut Microbiota Dysbiosis Is Associated with Elevated Bile Acids in Parkinson’s Disease |
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| المؤلفون: | Stewart F. Graham, Meghan Schilthuis, Noah Lubben, Randy Woltjer, Viviane Labrie, Patrik Brundin, Peipei Li, Jared Lamp, Elizabeth Ensink, Lena Brundin, Bryan A. Killinger, Irving E. Vega, Ali Yilmaz, J. Andrew Pospisilik, Ian Beddows |
| المصدر: | Metabolites; Volume 11; Issue 1; Pages: 29 Metabolites Metabolites, Vol 11, Iss 29, p 29 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Lithocholic acid, medicine.drug_class, Endocrinology, Diabetes and Metabolism, lcsh:QR1-502, microbiome, Gut flora, appendix, Biochemistry, digestive system, lcsh:Microbiology, Article, 03 medical and health sciences, chemistry.chemical_compound, Cecum, 0302 clinical medicine, Internal medicine, medicine, Microbiome, Molecular Biology, bile acids, Parkinson’s disease, gut, Bile acid, biology, Deoxycholic acid, digestive, oral, and skin physiology, fungi, food and beverages, Lipid metabolism, biology.organism_classification, medicine.disease, nervous system diseases, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Dysbiosis, 030217 neurology & neurosurgery |
| الوصف: | The gut microbiome can impact brain health and is altered in Parkinson’s disease (PD). The vermiform appendix is a lymphoid tissue in the cecum implicated in the storage and regulation of the gut microbiota. We sought to determine whether the appendix microbiome is altered in PD and to analyze the biological consequences of the microbial alterations. We investigated the changes in the functional microbiota in the appendix of PD patients relative to controls (n = 12 PD, 16 C) by metatranscriptomic analysis. We found microbial dysbiosis affecting lipid metabolism, including an upregulation of bacteria responsible for secondary bile acid synthesis. We then quantitatively measure changes in bile acid abundance in PD relative to the controls in the appendix (n = 15 PD, 12 C) and ileum (n = 20 PD, 20 C). Bile acid analysis in the PD appendix reveals an increase in hydrophobic and secondary bile acids, deoxycholic acid (DCA) and lithocholic acid (LCA). Further proteomic and transcriptomic analysis in the appendix and ileum corroborated these findings, highlighting changes in the PD gut that are consistent with a disruption in bile acid control, including alterations in mediators of cholesterol homeostasis and lipid metabolism. Microbially derived toxic bile acids are heightened in PD, which suggests biliary abnormalities may play a role in PD pathogenesis. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2218-1989 |
| DOI: | 10.3390/metabo11010029 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49fbad20611522780899effd0554caeTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a49fbad20611522780899effd0554cae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22181989 |
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| DOI: | 10.3390/metabo11010029 |