Standard Assays for the Study of Autophagy in the Ex Vivo Retina
| العنوان: | Standard Assays for the Study of Autophagy in the Ex Vivo Retina |
|---|---|
| المؤلفون: | Elena Sierra-Filardi, Beatriz Villarejo-Zori, Ignacio Ramírez-Pardo, Lorena Esteban-Martínez, Raquel Gómez-Sintes, Natalia Rodriguez-Muela, Patricia Boya, Ana Serrano-Puebla |
| المساهمون: | Consejo Superior de Investigaciones Científicas (España), Ministerio de Economía y Competitividad (España), European Commission |
| المصدر: | Cells, Vol 6, Iss 4, p 37 (2017) Cells Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, autophagy, retina, Programmed cell death, Retina, organotypic cultures, Central nervous system, Neurodegeneration, Autophagy, Review, General Medicine, Biology, medicine.disease, Cell biology, 03 medical and health sciences, lysosomes, mitophagy, 030104 developmental biology, medicine.anatomical_structure, lcsh:Biology (General), Mitophagy, medicine, lcsh:QH301-705.5, Intracellular, Ex vivo |
| الوصف: | Autophagy is a catabolic pathway that mediates the degradation and recycling of intracellular components, and is a key player in a variety of physiological processes in cells and tissues. Recent studies of autophagy in the eye suggest that this pathway is fundamental for the preservation of retinal homeostasis. Given its accessible location outside the brain, the retina is an ideal organ in which to study the central nervous system and a wide range of neuronal processes, from development to neurodegeneration. Here we review several methods used to assess autophagy in the retina in both physiological and pathological conditions. Research in the Boya Lab is supported by grants BFU2015-65623 (FEDER supported) and BFU2015-71869-REDT from Spain’s Ministerio de Economía y Competitividad (MINECO), COST Action Transautophagy (CA15138), and ITN H2020-MSCA-ITN-2017 DRIVE. BVZ is a recipient of a Ph.D. contract from the Fundación Tatiana Pérez de Guzmán el Bueno, and ASP has an FPI contract from MINECO. NRM and RGS have a Juan de la Cierva contract supported by MINECO. We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI). |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb9b6b4a1e70d65a6d7ae36557a8c8aTest http://hdl.handle.net/10261/156759Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4eb9b6b4a1e70d65a6d7ae36557a8c8a |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |