Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A
| العنوان: | Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A |
|---|---|
| المؤلفون: | Corry-Anke Brandsma, Don D. Sin, Alen Faiz, Diana A van der Plaat, Ivana Nedeljkovic, Dirkje S. Postma, Lies Lahousse, Judith M. Vonk, Kim de Jong, Cornelia M. van Duijn, David C. Nickle, Cleo C. van Diemen, H. Marike Boezen, Yohan Bossé, Guy Brusselle, Najaf Amin, Albert Hofman |
| المساهمون: | Epidemiology, Pulmonary Medicine, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE) |
| المصدر: | Journal of Allergy and Clinical Immunology, 139(2), 533-540. Mosby Inc. Journal of Allergy and Clinical Immunology, 139(2), 533-540. MOSBY-ELSEVIER |
| بيانات النشر: | MOSBY-ELSEVIER, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, medicine.medical_specialty, Genome-wide association study, GENETICS, Immunology, LEVEL, Single-nucleotide polymorphism, never-smokers, Biology, Bioinformatics, OBSTRUCTIVE PULMONARY-DISEASE, chronic obstructive pulmonary disease, 03 medical and health sciences, FEV1/FVC ratio, Internal medicine, medicine, Genetic predisposition, Immunology and Allergy, COPD, Risk factor, POLYMORPHISMS, METAANALYSIS, Genetic association, GENERAL-POPULATION, pulmonary function, STANDARDIZATION, ROTTERDAM, respiratory tract diseases, LUNG-FUNCTION, 030104 developmental biology, Expression quantitative trait loci, Hedgehog interacting protein |
| الوصف: | Background: Although a striking proportion (25% to 45%) of patients with chronic obstructive pulmonary disease are never-smokers, most genetic susceptibility studies have not focused on this group exclusively.Objective: The aim of this study was to identify common genetic variants associated with FEV1 and its ratio to forced vital capacity (FVC) in never-smokers.Methods: Genome-wide association studies were performed in 5070 never-smokers of the identification cohort LifeLines, and results (P Results: We identified associations between the FEV1/ FVC ratio and 5 common genetic variants in the identification cohort, and 2 of these associations were replicated. The 2 variants annotated to the genes hedgehog interacting protein (HHIP) and family with sequence similarity 13 member A (FAM13A) were shown to have an additive effect on FEV1/ FVC levels in the genetic risk score analysis; were associated with gene expression of HHIP and FAM13A in lung tissue, respectively; and were genome-wide significant in a meta-analysis including both identification and 4 verification cohorts (P Conclusion: The genes HHIP and FAM13A confer a risk for airway obstruction in general that is not driven exclusively by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease. |
| اللغة: | English |
| تدمد: | 0091-6749 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd2f01e4691df4689b943765dd82e43Test https://doi.org/10.1016/j.jaci.2016.06.062Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2dd2f01e4691df4689b943765dd82e43 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00916749 |
|---|