التفاصيل البيبلوغرافية
| العنوان: |
Endoscopic full-thickness biopsy of the gastric wall with defect closure by using an endoscopic suturing device: survival porcine study |
| المؤلفون: |
Rajan, Elizabeth, Gostout, Christopher J., Lurken, Matthew S., Stoltz, Gary J., Bernard, Cheryl E., Grover, Madhusudan, Farrugia, Gianrico, Aimore Bonin, Eduardo, Moran, Erica A., Locke, Richard G., Szarka, Lawrence A., Talley, Nicholas J., Deters, Jodie L., Miller, Charles A., Knipschield, Mary A. |
| المساهمون: |
The University of Newcastle. Faculty of Health & Medicine, School of Medicine and Public Health |
| بيانات النشر: |
Mosby |
| سنة النشر: |
2012 |
| المجموعة: |
NOVA: The University of Newcastle Research Online (Australia) |
| مصطلحات موضوعية: |
full-thickness gastric biopsy, interstitial cells of cajal, protein gene product 9.5, submucosal endoscopy with mucosal flap, submucosal fluid cushion, gastric wall, endoscopic suturing device, survival porcine study |
| الوصف: |
Background: The pathogenesis of several common gastric motility diseases and functional GI disorders remains essentially unexplained. Gastric wall biopsies that include the muscularis propria to evaluate the enteric nervous system, interstitial cells of Cajal, and immune cells can provide important insights for our understanding of the etiology of these disorders. Objectives: To determine the technical feasibility, reproducibility, and safety of performing a full-thickness gastric biopsy (FTGB) by using a submucosal endoscopy with mucosal flap (SEMF) technique; the technical feasibility, reproducibility, and safety of tissue closure by using an endoscopic suturing device; the ability to identify myenteric ganglia in resected specimens; and the long-term safety. Design: Single center, preclinical survival study. Setting: Animal research laboratory, developmental endoscopy unit. Subjects: Twelve domestic pigs. Interventions: Animals underwent an SEMF procedure with gastric muscularis propria resection. The resultant offset mucosal entry site was closed by using an endoscopic suturing device. Animals were kept alive for 2 weeks. Main Outcome Measurements: The technical feasibility, reproducibility, and safety of the procedure; the clinical course of the animals; the histological and immunochemical evaluation of the resected specimen to determine whether myenteric ganglia were present in the sample. Results: FTGB was performed by using the SEMF technique in all 12 animals. The offset mucosal entry site was successfully closed by using the suturing device in all animals. The mean resected tissue specimen size was 11 mm. Mean total procedure time was 61 minutes with 2 to 4 interrupted sutures placed per animal. Histology showed muscularis propria and serosa, confirming full-thickness resections in all animals. Myenteric ganglia were visualized in 11 of 12 animals. The clinical course was uneventful. Repeat endoscopy and necropsy at 2 weeks showed absence of ulceration at both the mucosal entry sites and overlying the ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
0016-5107 |
| العلاقة: |
Gastrointestinal Endoscopy Vol. 76, Issue 5, p. 1014-1019; http://hdl.handle.net/1959.13/1308497Test; uon:21656 |
| الإتاحة: |
http://hdl.handle.net/1959.13/1308497Test |
| رقم الانضمام: |
edsbas.E04DC765 |
| قاعدة البيانات: |
BASE |
