Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients
| العنوان: | Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients |
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| المؤلفون: | Loxham, Matthew, Davies, Donna E. |
| المصدر: | The Journal of Allergy and Clinical Immunology |
| بيانات النشر: | Mosby, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | AhR, Aryl hydrocarbon receptor, tight junction, eQTL, Expression quantitative trait locus, AJ, Adherens junction, Respiratory Mucosa, SC, Subject cluster, BHR, Bronchial hyperresponsiveness, GC, Gene cluster, CDHR3, Cadherin-related family member 3, PCDH1, Protocadherin 1, NK, Natural killer, homeostasis, ILC, Innate lymphoid cell, cytokine, EGFR, Epidermal growth factor receptor, ORMDL3, Orosomucoid-like 3, Animals, Humans, Genetic Predisposition to Disease, innate immunity, TSLP, Thymic stromal lymphopoietin, SNP, Single nucleotide polymorphism, DUOX1, Dual oxidase 1, Reviews and Feature Article, TJ, Tight junction, DC, Dendritic cell, Asthma, Phenotype, GST, Glutathione-S-transferase, ILC2, Type 2 innate lymphoid cell, GWAS, Genome-wide association study, TLR, Toll-like receptor |
| الوصف: | The bronchial epithelium is continuously exposed to a multitude of noxious challenges in inhaled air. Cellular contact with most damaging agents is reduced by the action of the mucociliary apparatus and by formation of a physical barrier that controls passage of ions and macromolecules. In conjunction with these defensive barrier functions, immunomodulatory cross-talk between the bronchial epithelium and tissue-resident immune cells controls the tissue microenvironment and barrier homeostasis. This is achieved by expression of an array of sensors that detect a wide variety of viral, bacterial, and nonmicrobial (toxins and irritants) agents, resulting in production of many different soluble and cell-surface molecules that signal to cells of the immune system. The ability of the bronchial epithelium to control the balance of inhibitory and activating signals is essential for orchestrating appropriate inflammatory and immune responses and for temporally modulating these responses to limit tissue injury and control the resolution of inflammation during tissue repair. In asthmatic patients abnormalities in many aspects of epithelial barrier function have been identified. We postulate that such abnormalities play a causal role in immune dysregulation in the airways by translating gene-environment interactions that underpin disease pathogenesis and exacerbation. |
| اللغة: | English |
| تدمد: | 1097-6825 0091-6749 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::a2173200b3836170523819c9999e1f18Test http://europepmc.org/articles/PMC5457128Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........a2173200b3836170523819c9999e1f18 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10976825 00916749 |
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