دورية أكاديمية
Epigenome-wide meta-analysis of DNA methylation and childhood asthma
| العنوان: | Epigenome-wide meta-analysis of DNA methylation and childhood asthma |
|---|---|
| المؤلفون: | Reese, SE, Xu, C-J, den Dekker, HT, Lee, MK, Sikdar, S, Ruiz-Arenas, C, Merid, SK, Rezwan, FI, Page, CM, Ullemar, V, Melton, PE, Oh, SS, Yang, IV, Burrows, K, Soderhall, C, Jima, DD, Gao, L, Arathimos, R, Kupers, LK, Wielscher, M, Rzehak, P, Lahti, J, Laprise, C, Madore, A-M, Ward, J, Bennett, BD, Wang, T, Bell, DA, Vonk, JM, Haberg, SE, Zhao, S, Karlsson, R, Hollams, E, Hu, D, Richards, AJ, Bergstrom, A, Sharp, GC, Felix, JF, Bustamante, M, Gruzieva, O, Maguire, RL, Gilliland, F, Baiz, N, Nohr, EA, Corpeleijn, E, Sebert, S, Karmaus, W, Grote, V, Kajantie, E, Magnus, MC, Ortqvist, AK, Eng, C, Liu, AH, Kull, I, Jaddoe, VWV, Sunyer, J, Kere, J, Hoyo, C, Annesi-Maesano, I, Arshad, SH, Koletzko, B, Brunekreef, B, Binder, EB, Raikkonen, K, Reischl, E, Holloway, JW, Jarvelin, M-R, Snieder, H, Kazmi, N, Breton, CV, Murphy, SK, Pershagen, G, Anto, JM, Relton, CL, Schwartz, DA, Burchard, EG, Huang, R-C, Nystad, W, Almqvist, C, Henderson, AJ, Melen, E, Duijts, L, Koppelman, GH, London, SJ |
| بيانات النشر: | Mosby |
| سنة النشر: | 2019 |
| المجموعة: | University of Tasmania: UTas ePrints |
| مصطلحات موضوعية: | epigenetics, asthma, childhood, drug development, methylation, newborn |
| الوصف: | Background: Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis.Objective: We sought to identify differential DNA methylation in newborns and children related to childhood asthma.Methods: Within the Pregnancy And Childhood Epigenetics consortium, we performed epigenome-wide meta-analyses of school-age asthma in relation to CpG methylation (Illumina450K) in blood measured either in newborns, in prospective analyses, or cross-sectionally in school-aged children. We also identified differentially methylated regions.Results: In newborns (8 cohorts, 668 cases), 9 CpGs (and 35 regions) were differentially methylated (epigenome-wide significance, false discovery rate IL5RA and KCNH2.Conclusion: Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age. Cross-sectional associations in children can reflect both risk for and effects of disease. Asthma-related differential methylation in blood in children was substantially replicated in eosinophils and respiratory epithelium. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://eprints.utas.edu.au/36616/1/144385%20-%20epigenome%20wide%20meta%20analysis.pdfTest; Reese, SE, Xu, C-J, den Dekker, HT, Lee, MK, Sikdar, S, Ruiz-Arenas, C, Merid, SK, Rezwan, FI, Page, CM, Ullemar, V, Melton, PE orcid:0000-0003-4026-2964 , Oh, SS, Yang, IV, Burrows, K, Soderhall, C, Jima, DD, Gao, L, Arathimos, R, Kupers, LK, Wielscher, M, Rzehak, P, Lahti, J, Laprise, C, Madore, A-M, Ward, J, Bennett, BD, Wang, T, Bell, DA, Vonk, JM, Haberg, SE, Zhao, S, Karlsson, R, Hollams, E, Hu, D, Richards, AJ, Bergstrom, A, Sharp, GC, Felix, JF, Bustamante, M, Gruzieva, O, Maguire, RL, Gilliland, F, Baiz, N, Nohr, EA, Corpeleijn, E, Sebert, S, Karmaus, W, Grote, V, Kajantie, E, Magnus, MC, Ortqvist, AK, Eng, C, Liu, AH, Kull, I, Jaddoe, VWV, Sunyer, J, Kere, J, Hoyo, C, Annesi-Maesano, I, Arshad, SH, Koletzko, B, Brunekreef, B, Binder, EB, Raikkonen, K, Reischl, E, Holloway, JW, Jarvelin, M-R, Snieder, H, Kazmi, N, Breton, CV, Murphy, SK, Pershagen, G, Anto, JM, Relton, CL, Schwartz, DA, Burchard, EG, Huang, R-C, Nystad, W, Almqvist, C, Henderson, AJ, Melen, E, Duijts, L, Koppelman, GH and London, SJ 2019 , 'Epigenome-wide meta-analysis of DNA methylation and childhood asthma' , Journal of Allergy and Clinical Immunology, vol. 143, no. 6 , pp. 2062-2074 , doi: https://doi.org/10.1016/j.jaci.2018.11.043Test . |
| الإتاحة: | https://doi.org/10.1016/j.jaci.2018.11.043Test https://eprints.utas.edu.au/36616Test/ https://eprints.utas.edu.au/36616/1/144385%20-%20epigenome%20wide%20meta%20analysis.pdfTest |
| رقم الانضمام: | edsbas.CE466D68 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |