Molecular Aspects of HTLV-1 Entry: Functional Domains of the HTLV-1 Surface Subunit (SU) and Their Relationships to the Entry Receptors
| العنوان: | Molecular Aspects of HTLV-1 Entry: Functional Domains of the HTLV-1 Surface Subunit (SU) and Their Relationships to the Entry Receptors |
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| المؤلفون: | Laurence Bénit, Frank W. Ruscetti, Sophie Lambert, Claudine Pique, Manuella Bouttier, Kathryn S. Jones, Olivier Hermine |
| المصدر: | Viruses Viruses, Vol 3, Iss 6, Pp 794-810 (2011) |
| بيانات النشر: | Molecular Diversity Preservation International (MDPI), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Env, viruses, lcsh:QR1-502, Review, lcsh:Microbiology, Retrovirus, Viral envelope, Viral entry, Virology, Neuropilin 1, Neuropilin, Animals, Humans, Receptor, Infectivity, Human T-lymphotropic virus 1, biology, virus diseases, Gene Products, env, Virus Internalization, biology.organism_classification, HTLV-I Infections, Protein Structure, Tertiary, retrovirus, Infectious Diseases, Receptors, Virus, viral entry, proteoglycans, neuropilin, GLUT |
| الوصف: | The initial step in retroviral infection involves specific interactions between viral envelope proteins (Env) and specific receptors on the surface of target cells. For many years, little was known about the entry receptors for HTLV-1. During this time, however, functional domains of the HTLV-1 Env were identified by analyzing the effects of neutralizing antibodies and specific mutations in Env on HTLV-1 infectivity. More recent studies have revealed that HTLV-1 infectivity involves interactions with three different molecules: heparan sulfate proteoglycans (HSPG), the VEGF-165 receptor Neuropilin 1 (NRP-1) and glucose transporter type 1 (GLUT1). Here, we revisit previously published data on the functional domains of Env in regard to the recent knowledge acquired about this multi-receptor complex. We also discuss the similarities and differences between HTLV-1 and other deltaretroviruses in regards to receptor usage. |
| اللغة: | English |
| تدمد: | 1999-4915 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361af81ccb8037933efd0bcd3f17a8f6Test http://europepmc.org/articles/PMC3185769Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....361af81ccb8037933efd0bcd3f17a8f6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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