Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size
| العنوان: | Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size |
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| المؤلفون: | Yuhui Ma, Zhenqiang Wu, Zhifang Chai, Yuanyuan Li, Peng Zhang, Xiao He, Zhiyong Zhang, Lu Peng, Yayun Ding, Junzhe Zhang, Jing Zhang |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 15; Issue 4; Pages: 6072-6085 International Journal of Molecular Sciences, Vol 15, Iss 4, Pp 6072-6085 (2014) |
| بيانات النشر: | Molecular Diversity Preservation International (MDPI), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Pulmonary toxicity, Nanoparticle, agglomerates, Metal Nanoparticles, surface chemistry, medicine.disease_cause, lcsh:Chemistry, Lipid peroxidation, chemistry.chemical_compound, Mice, size distribution, lcsh:QH301-705.5, Lung, Spectroscopy, Vehicle Emissions, chemistry.chemical_classification, nano-ceria, Mice, Inbred ICR, medicine.diagnostic_test, General Medicine, Cerium, Computer Science Applications, pulmonary toxicity, Bronchoalveolar Lavage Fluid, Oxidation-Reduction, Surface Properties, Inorganic chemistry, Acid Phosphatase, Lung injury, Catalysis, Article, Inorganic Chemistry, medicine, Animals, Humans, Physical and Theoretical Chemistry, Particle Size, Molecular Biology, Reactive oxygen species, L-Lactate Dehydrogenase, Organic Chemistry, Oxidative Stress, Bronchoalveolar lavage, lcsh:Biology (General), lcsh:QD1-999, chemistry, Biophysics, Particle size, Lipid Peroxidation, Reactive Oxygen Species, Oxidative stress |
| الوصف: | Ceria nanoparticles (nano-ceria) have recently gained a wide range of applications, which might pose unwanted risks to both the environment and human health. The greatest potential for the environmental discharge of nano-ceria appears to be in their use as a diesel fuel additive. The present study was designed to explore the pulmonary toxicity of nano-ceria in mice after a single exposure via intratracheal instillation. Two types of nano-ceria with the same distribution of a primary size (3–5 nm), but different redox activity, were used: Ceria-p, synthesized by a precipitation route, and Ceria-h, synthesized by a hydrothermal route. Both Ceria-p and Ceria-h induced oxidative stress, inflammatory responses and cytotoxicity in mice, but their toxicological profiles were quite different. The mean size of Ceria-p agglomerates was much smaller compared to Ceria-h, thereby causing a more potent acute inflammation, due to their higher number concentration of agglomerates and higher deposition rate in the deep lung. Ceria-h had a higher reactivity to catalyzing the generation of reactive oxygen species (ROS), and caused two waves of lung injury: bronchoalveolar lavage (BAL) inflammation and cytotoxicity in the early stage and redox-activity-evoked lipid peroxidation and pro-inflammation in the latter stage. Therefore, the size distribution of ceria-containing agglomerates in the exhaust, as well as their surface chemistry are essential characteristics to assess the potential risks of using nano-ceria as a fuel additive. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7605d42bd436910d326ba201c7b90e5Test http://europepmc.org/articles/PMC4013616Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d7605d42bd436910d326ba201c7b90e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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