Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)
| العنوان: | Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE) |
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| المؤلفون: | Marianna Giannini, Alfred Cuschieri, Gerardo F. Goya, Luciana Dente, M. Pilar Calatayud, Vittoria Raffa, Martina Giannaccini |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 15, Iss 1, Pp 1590-1605 (2014) International Journal of Molecular Sciences; Volume 15; Issue 1; Pages: 1590-1605 Zaguán. Repositorio Digital de la Universidad de Zaragoza instname |
| بيانات النشر: | Molecular Diversity Preservation International (MDPI), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | genetic structures, Xenopus, Retinal Pigment Epithelium, Catalysis, Article, magnetic nanoparticle (MNP), intraocular delivery, retinal pigmented epithelium (RPE), Xenopus laevis, lcsh:Chemistry, Inorganic Chemistry, chemistry.chemical_compound, Drug Delivery Systems, medicine, Animals, Physical and Theoretical Chemistry, Magnetite Nanoparticles, lcsh:QH301-705.5, Molecular Biology, Zebrafish, Spectroscopy, Retina, Retinal pigment epithelium, biology, Organic Chemistry, Retinal, General Medicine, Anatomy, biology.organism_classification, eye diseases, Computer Science Applications, Cell biology, medicine.anatomical_structure, lcsh:Biology (General), lcsh:QD1-999, chemistry, Drug delivery, Magnetic nanoparticles, Choroid, sense organs, Injections, Intraocular |
| الوصف: | One of the most challenging efforts in drug delivery is the targeting of the eye. The eye structure and barriers render this organ poorly permeable to drugs. Quite recently the entrance of nanoscience in ocular drug delivery has improved the penetration and half-life of drugs, especially in the anterior eye chamber, while targeting the posterior chamber is still an open issue. The retina and the retinal pigment epithelium/choroid tissues, located in the posterior eye chamber, are responsible for the majority of blindness both in childhood and adulthood. In the present study, we used magnetic nanoparticles (MNPs) as a nanotool for ocular drug delivery that is capable of specific localization in the retinal pigmented epithelium (RPE) layer. We demonstrate that, following intraocular injection in Xenopus embryos, MNPs localize specifically in RPE where they are retained for several days. The specificity of the localization did not depend on particle size and surface properties of the MNPs used in this work. Moreover, through similar experiments in zebrafish, we demonstrated that the targeting of RPE by the nanoparticles is not specific for the Xenopus species. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51821541a08cb77bdf9a2f53f2014acaTest http://europepmc.org/articles/PMC3907888Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....51821541a08cb77bdf9a2f53f2014aca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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