دورية أكاديمية
Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62
| العنوان: | Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62 |
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| المؤلفون: | Wang, Yanan, Zhang, Nan, Zhang, Luyao, Li, Ran, Fu, Wan, Ma, Ke, Li, Xue, Wang, Lina, Wang, Jiadong, Zhang, Hongquan, Gu, Wei, Zhu, Wei-Guo, Zhao, Ying |
| المساهمون: | Zhu, WG, Zhao, Y (reprint author), Peking Univ, Hlth Sci Ctr,Dept Biochem & Mol Biol, Key Lab Carcinogenesis & Translat Res,Sch Basic M, Minist Educ,Beijing Key Lab Prot Posttranslat Mod, Beijing 100191, Peoples R China., Zhu, WG (reprint author), Peking Tsinghua Univ, Ctr Life Sci, Beijing 100871, Peoples R China., Zhu, WG (reprint author), Shenzhen Univ, Sch Med, Dept Biochem & Mol Biol, Shenzhen 518060, Peoples R China., Peking Univ, Hlth Sci Ctr,Dept Biochem & Mol Biol, Key Lab Carcinogenesis & Translat Res,Sch Basic M, Minist Educ,Beijing Key Lab Prot Posttranslat Mod, Beijing 100191, Peoples R China., Peking Univ, Inst Syst Biomed, Sch Basic Med Sci, Beijing 100191, Peoples R China., Peking Univ, Dept Radiat Med, Sch Basic Med Sci, Beijing 100191, Peoples R China., Peking Univ, Dept Anat Histol & Embryol, Hlth Sci Ctr, Beijing 100191, Peoples R China., Columbia Univ, Inst Canc Genet, Coll Phys & Surg, New York, NY 10032 USA., Columbia Univ, Dept Pathol & Cell Biol, Coll Phys & Surg, New York, NY 10032 USA., Peking Tsinghua Univ, Ctr Life Sci, Beijing 100871, Peoples R China., Shenzhen Univ, Sch Med, Dept Biochem & Mol Biol, Shenzhen 518060, Peoples R China. |
| المصدر: | PubMed ; SCI |
| بيانات النشر: | MOLECULAR CELL |
| سنة النشر: | 2016 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | DNA damage,autophagy,histone ubiquitination,p62, TRANSCRIPTION FACTOR NRF2, DOUBLE-STRAND BREAKS, SELECTIVE AUTOPHAGY, CELL-DEATH, P62, DEGRADATION, REPAIR, P62/SQSTM1, PROTEINS, BINDING |
| الوصف: | Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome, and loss of autophagy has been linked to increased genome instability. Here, we report that loss of autophagy is coupled to reduced histone H2A ubiquitination after DNA damage. p62/SQSTM1, which accumulates in autophagy-defective cells, directly binds to and inhibits nuclear RNF168, an E3 ligase essential for histone H2A ubiquitination and DNA damage responses. As a result, DNA repair proteins such as BRCA1, RAP80, and Rad51 cannot be recruited to the sites of DNA double-strand breaks (DSBs), which impairs DSB repair. Moreover, nuclear-localized p62 increased the sensitivity of tumor cells to radiation both in vitro and in vivo, and this required its interaction with RNF168. Our findings indicate that autophagy-deficiency-induced p62 accumulation results in inhibition of histone ubiquitination and highlight the complex relationship between autophagy and the DNA damage response. ; 973 Projects [2011CB910100, 2011CB504200]; National Natural Science Foundation of China [81222028, 81321003, 81472581, 91319302, 31261140372]; Ministry of Science and Technology of China [B70001] ; SCI(E) ; PubMed ; ARTICLE ; zhuweiguo@szu.edu.cn; zhaoying0812@bjmu.edu.cn ; 1 ; 34-48 ; 63 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1097-2765 1097-4164 |
| العلاقة: | MOLECULAR CELL.2016,63(1),34-48.; 1432344; http://hdl.handle.net/20.500.11897/491965Test; WOS:000381618700006 |
| DOI: | 10.1016/j.molcel.2016.05.027 |
| الإتاحة: | https://doi.org/20.500.11897/491965Test https://doi.org/10.1016/j.molcel.2016.05.027Test https://hdl.handle.net/20.500.11897/491965Test |
| رقم الانضمام: | edsbas.703C2D79 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10972765 10974164 |
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| DOI: | 10.1016/j.molcel.2016.05.027 |