التفاصيل البيبلوغرافية
| العنوان: |
Protective Effect of Genistein on the Morphine-Induced Kidney Disorders in Male Mice. |
| المؤلفون: |
Jalili, Cyrus1,2, Rashidi, Iraj2, Roshankhah, Shiva2, Jalili, Faramarz3, Salahshoor, Mohammad Reza2 reza.salahshoor@yahoo.com |
| المصدر: |
Electronic Journal of General Medicine. 2020, Vol. 17 Issue 3, p1-7. 7p. |
| مصطلحات موضوعية: |
*KIDNEY disease prevention, *ANIMAL experimentation, *ANTHROPOMETRY, *BIOMARKERS, *COMPARATIVE studies, *CREATININE, *ENZYME-linked immunosorbent assay, *KIDNEY function tests, *KIDNEY glomerulus, *KIDNEYS, *KIDNEY diseases, *LACTATE dehydrogenase, *MICE, *MORPHINE, *NITRIC oxide, *PHYSIOLOGIC salines, *RESEARCH funding, *STATISTICAL sampling, *STAINS & staining (Microscopy), *STATISTICS, *DATA analysis, *QUANTITATIVE research, *GENISTEIN, *DESCRIPTIVE statistics, *BLOOD urea nitrogen, *ONE-way analysis of variance |
| مصطلحات جغرافية: |
IRAN |
| مستخلص: |
Background: Morphine is a member of the naturally occurring phenanthrene alkaloids of opium. Genistein is a phytoestrogen, present in soy products. This study was designed to evaluate protective effects of genistein against morphine induced damages to the kidneys of mice. Methods: In this study, 48 male mice were randomly assigned to 8 groups: control (saline), morphine treated group (10 mg/kg/day); genistein groups (1, 2, 4 mg/kg/day) and morphine plus genistein treated group. Drugs were administrated intraperitoneally for 30 consequent days. Weight of animals and kidneys, glomeruli characteristics, kidney function markers and blood serum nitric oxide level has been studied. Result: The results indicated that morphine administration significantly increased Lactate dehydrogenase (LDH), Blood urea nitrogen (BUN), creatinine and nitric oxide levels compared to the control ( saline) group (P<0.05). Genistein in all doses and genistein plus morphine at the dose of 4 mg/kg significantly decreased LDH, BUN, creatinine, glomerular diameter and nitric oxide levels compared to the control and morphine groups (p<0.05). Conclusion: It seems that genistein administration improved kidney damages induced by morphine in mice. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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