دورية أكاديمية
OPTIMIZATION OF SOLID-PHASE SYNTHESIS OF POLYAMIDE NUCLEIC ACID MIMETICS WITH APPLICATION OF MALDI-TOF MASS-SPECTROMETRY
| العنوان: | OPTIMIZATION OF SOLID-PHASE SYNTHESIS OF POLYAMIDE NUCLEIC ACID MIMETICS WITH APPLICATION OF MALDI-TOF MASS-SPECTROMETRY |
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| المؤلفون: | M. V. Shirayeva, Yu. G. Kirillova, E. D. Nikol’Skaya, D. I. Prokhorov, I. P. Smirnov, G. E. Pozmogova |
| المصدر: | Тонкие химические технологии, Vol 8, Iss 1, Pp 87-95 (2013) |
| بيانات النشر: | MIREA - Russian Technological University, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | полиамидные миметики нуклеиновых кислот, пептидно-нуклеиновые кислоты (пнк), твердофазный синтез, maldi-tof-масс-спектрометрия, polyamide nucleic acid mimetics (panam), peptide nucleic acids (pna), solid phase synthesis, maldi-tof mass-spectrometry, Chemistry, QD1-999 |
| الوصف: | The solid-phase synthesis of a tetrameric model sequence of polyamide nucleic acid mimetics (PANAM) incorporating terminal chiral and charged unit was performed. As a result during the synthesis and cleavage from the resin the tendency of PANAM with the N-terminal negatively charged monomer to cyclization with simultaneous N-acyl transfer of carboxyethyl base residue was found. Application of MALDI-TOF mass - spectrometry allowed us to find suitable conditions for obtaining PANAM oligomers without the significant amount of by-products. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 2410-6593 2686-7575 |
| العلاقة: | https://www.finechem-mirea.ru/jour/article/view/659Test; https://doaj.org/toc/2410-6593Test; https://doaj.org/toc/2686-7575Test |
| الوصول الحر: | https://doaj.org/article/c2b7fce3f4114d9582bc4c27a07f13adTest |
| رقم الانضمام: | edsdoj.2b7fce3f4114d9582bc4c27a07f13ad |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 24106593 26867575 |
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