Clinical value of combining transvaginal contrast-enhanced ultrasonography with serum human epididymisprotein-4 and the resistance index for early-stage epithelial ovarian cancer
| العنوان: | Clinical value of combining transvaginal contrast-enhanced ultrasonography with serum human epididymisprotein-4 and the resistance index for early-stage epithelial ovarian cancer |
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| المؤلفون: | Zheng Qichao, Tang Jie, Wang Ying, Wu Meng, Li Ping |
| المصدر: | Saudi Medical Journal, Vol 38, Iss 6, Pp 592-597 (2017) Saudi Medical Journal |
| بيانات النشر: | Ministry of Defence and Aviation, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, lcsh:Medicine, Carcinoma, Ovarian Epithelial, Gastroenterology, Group B, resistance index, 03 medical and health sciences, Ovarian tumor, 0302 clinical medicine, Internal medicine, medicine, Carcinoma, Humans, Contrast-enhanced ultrasonography, human epididymis protein 4, Epithelial ovarian cancer, Neoplasms, Glandular and Epithelial, Stage (cooking), Ultrasonography, Gynecology, Ovarian Neoplasms, business.industry, lcsh:R, General Medicine, Blood Proteins, medicine.disease, Blood proteins, 030104 developmental biology, 030220 oncology & carcinogenesis, Vagina, Female, Original Article, Differential diagnosis, business |
| الوصف: | Objectives: To increase accuracy of the detection and differential diagnosis of the early epithelial ovarian cancer (EOC) with transvaginal contrast-enhanced ultrasonography (TVCEUS) combining serum human epididymisprotein 4 (HE4), and resistance index (RI). Methods : This retrospectively case-control study of 230 patients with ovarian tumors were reviewed at the Department of Gynecology and Obstetrics, Zhongnan Hospital, Wuhan University, Wuhan, China between June 2008 and September 2015. Before the operation of 110 cases with EOC (Group A) and 120 cases of patients with benign ovarian tumor (Group B), we observe and calculate both Groups’ tumor vascular contrast-enhanced ultrasonography morphology scores (U), time-intensity curve (TIC) of contrast-enhanced ultrasonography, HE4, and RI. Results were compared with the histopathological analysis results. Results : The ultrasonography morphology scores, peak intensity (PI) enhancement rate (ER) with the parameters of the TIC and HE4 are higher in Group A compared with patients in Group B and the RI was lower than Group B. The detection rates for all indexes in the benign and malignant groups and their comparisons to the histopathological results were determined. The detection rate differences for HE4 ( p =0.001), RI ( p =0.001), U ( p =0.001), PI ( p =0.001), and ER ( p =0.001) were all statistically significant ( p less than 0.05). Conclusion : The high clinical value through combined TVCEUS, HE4, and RI detection can increase the sensitivity of the diagnosis and differential diagnosis of the early EOC. Saudi Med J 2017; Vol. 38 (6): 592-597 doi:10.15537/smj.2017.6.19790 How to cite this article: Meng W, Ying W, Qichao Z, Ping L, Jie T.Clinical value of combining transvaginal contrast-enhanced ultrasonography with serum human epididymisprotein-4 and the resistance index for early-stage epithelial ovarian cancer. Saudi Med J. 2017 Jun;38(6):592-597. doi: 10.15537/smj.2017.6.19790. |
| اللغة: | English |
| تدمد: | 1658-3175 0379-5284 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724662031981afc80f02f9c236e1808bTest https://www.smj.org.sa/index.php/smj/article/view/smj.2017.6.19790/10273Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....724662031981afc80f02f9c236e1808b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16583175 03795284 |
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