The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis
| العنوان: | The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis |
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| المؤلفون: | Tom H. Karlsen, Monica Bocciolone, Mareike Wendorff, Mauro D'Amato, Anna Ludovica Fracanzani, Leonardo Terranova, Pietro Invernizzi, Luigia Scudeller, María Hernández-Tejero, Maurizio Cecconi, David Jiménez, Antonio Pesenti, Anna Latiano, Sandra May, Luigi Santoro, Nicole Braun, Valeria Rimoldi, Jeanette Erdmann, Mariella D'Angiò, Giorgio Costantino, Sara Marsal, Antonio Voza, Fatima Aziz, Xiaoli Yi, Wolfgang Peter, Marina Elena Cazzaniga, Giuseppe Foti, Antonio Julià, Lars Wienbrandt, Rosa Nieto, Cristina Cea, Maria Eloina Figuera Basso, Maria Carrabba, Michele Ciccarelli, Javier Martín, Adriana Palom, Paolo Bonfanti, Andrea Caballero-Garralda, Manuel Romero Gómez, Koldo Garcia-Etxebarria, Guido Baselli, Rosanna Asselta, Giuseppe Matullo, Ilaria My, Francisco Mesonero, Serena Aneli, Javier Fernández, Marit Mæhle Grimsrud, Pedro M. Rodrigues, Luis Téllez, Johannes R. Hov, Elvezia Maria Paraboschi, Enrique Navas, Andrea Gori, Flora Peyvandi, Francesco Blasi, Orazio Palmieri, Ana Lleo de Nalda, Marco Schaefer, Anja Tanck, Jan Christian Kässens, José Ferrusquía-Acosta, Giacomo Grasselli, Wolfgang Albrecht, Maria Buti, Tenghao Zheng, Serena Pelusi, Daniele Prati, Laura Rachele Bettini, Nilda Martinez, Silvano Bosari, M.A. Rodríguez-Gandía, Alessandra Bandera, Leticia Moreira, Paoletta Preatoni, Giulia Cardamone, Albert Blanco-Grau, Tanja Wesse, Aaron Blandino Ortiz, Marina Baldini, Hayato Kurihara, Beatriz Mateos, Jesus M. Banales, Alberto Zanella, Roberta Gualtierotti, Salvatore Badalamenti, David Ellinghaus, Tomás Pumarola, Luca Valenti, Maria Grazia Valsecchi, Chiara Milani, Martin Schulzky, Alba-Estela Garcia-Fernandez, Aurora Solier, Pedro Castro, Ferruccio Ceriotti, Beatriz Jiménez, Maria del Mar Riveiro Barciela, Stefano Duga, Carmen Quereda, Luisa Roade, Michael Wittig, Anna Peschuck, Andre Franke, Valter Monzani, Ricardo Ferrer Roca, Luis Bujanda, F. Martinelli-Boneschi, Adolfo Garrido Chercoles, Raúl de Pablo, Laura Izquierdo-Sanchez, Paola Faverio, Alessandro Protti, Hesham ElAbd, Monica Miozzo, Elena Sandoval, Agustín Albillos, Marialbert Acosta-Herrera, David Pestana, Paolo Omodei, Trine Folseraas, Andrea Biondi, Paolo Tentorio, Florian Uellendahl-Werth, Claudio Angelini, Frauke Degenhardt, Alessio Aghemo, Francisco Rodriguez-Frias |
| المساهمون: | German Research Foundation, Canica, Swiss Cancer League, Ministero dell'Istruzione, dell'Università e della Ricerca, Fonds Schleswig-Holstein, Federal Ministry of Education and Research (Germany), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España) |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | MedRxiv, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | German, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), language, Genome-Wide Association Analysis, Library science, Christian ministry, Biobank, language.human_language |
| الوصف: | [Background] Respiratory failure is a key feature of severe Covid-19 and a critical driver of mortality, but for reasons poorly defined affects less than 10% of SARS-CoV-2 infected patients. [Methods] We included 1,980 patients with Covid-19 respiratory failure at seven centers in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe (Milan, Monza, Madrid, San Sebastian and Barcelona) for a genome-wide association analysis. After quality control and exclusion of population outliers, 835 patients and 1,255 population-derived controls from Italy, and 775 patients and 950 controls from Spain were included in the final analysis. In total we analyzed 8,582,968 single-nucleotide polymorphisms (SNPs) and conducted a metaanalysis of both case-control panels. [Results] We detected cross-replicating associations with rs11385942 at chromosome 3p21.31 and rs657152 at 9q34, which were genome-wide significant (P [Conclusions] We herein report the first robust genetic susceptibility loci for the development of respiratory failure in Covid-19. Identified variants may help guide targeted exploration of severe Covid19 pathophysiology. The IKMB's core facilities received infrastructure support by the Deutsche Forschungsgemeinschaft (DFG) Cluster of Excellence "Precision Medicine in Chronic Inflammation" (PMI, EXC2167). The project also received support through a philanthropic donation by Stein Erik Hagen and Canica AS. L.V. was funded by the Fondazione IRCCS Ca’ Granda «COVID-19 Biobank» research grant. This work was also supported by the Ministero dell’Istruzione, dell’Università e della Ricerca – MIUR project "Dipartimenti di Eccellenza 2018 – 2022" (n° D15D18000410001) to the Department of Medical Sciences, University of Torino. The IKMB authors received financial support from the UKSH Foundation "Gutes Tun!" (special thanks to Alexander Eck, Jenspeter Horst and Jens Scholz) and the German Federal Ministry of Education and Research (BMBF; grant ID 01KI20197). HLA-Typing was performed and supported by the Stefan-MorschStiftung. M.A.H was supported by the Spanish Ministry of Science and Innovation ‘JdC fellowship IJC2018-035131-I. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc549d801f832e716e32bdbab0a86e8Test http://hdl.handle.net/10261/213231Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2cc549d801f832e716e32bdbab0a86e8 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |