Interaction of incidental microbleeds and prior use of antithrombotics with early hemorrhagic transformation: Causative or protective?
| العنوان: | Interaction of incidental microbleeds and prior use of antithrombotics with early hemorrhagic transformation: Causative or protective? |
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| المؤلفون: | Bichun Ouyang, David S Liebeskind, Yousef Mohammad, Monica Khunger, Konark Malhotra |
| المصدر: | Annals of Indian Academy of Neurology Annals of Indian Academy of Neurology, Vol 19, Iss 4, Pp 467-471 (2016) |
| بيانات النشر: | Medknow, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | medicine.medical_specialty, Acute ischemic stroke, Logistic regression, lcsh:RC346-429, 03 medical and health sciences, 0302 clinical medicine, cerebral microbleeds, Diabetes mellitus, Internal medicine, Antithrombotic, Hyperlipidemia, medicine, lcsh:Neurology. Diseases of the nervous system, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Retrospective cohort study, medicine.disease, gradient echo magnetic resonance imaging, hemorrhagic transformation, Increased risk, 030220 oncology & carcinogenesis, Anesthesia, Cardiology, Original Article, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | Background: Gradient echo (GRE) sequence of magnetic resonance imaging (MRI) is a sensitive tool to detect hemorrhagic transformation (HT) and old cerebral microbleeds (CMBs). Presence of CMBs and prior use of antithrombotics pose a risk of HT in ischemic stroke. We evaluated the association of CMBs and antithrombotic use with resultant HT in acute ischemic stroke (AIS). Methods: This retrospective study included AIS patients admitted to our center between January 2009 and August 2010 who underwent GRE-weighted MRI within 48 h of admission. Demographic and clinical data including diabetes mellitus, hypertension, hyperlipidemia, prior intake of antiplatelets/anticoagulants/statins, and presence of CMBs at admission were collected and compared between patients who developed HT and those who did not. We did a multivariate analysis using logistic regression to assess the effect of CMBs and prior use of antithrombotic agents on the risk of development for early HT in ischemic stroke. Results: Of 529 AIS patients, 81 (15%) were found to have HT during the initial hospital course. CMBs were found in only 9 of 81 patients (11%) with HT and in 40 out of remaining 448 patients (9%) who did not develop HT. The presence of CMBs was not associated with increased risk of HT (P = 0.53). However, prior use of antiplatelets (33% vs. 47% in the patients without HT, P = 0.02) was associated with decreased risk of HT in ischemic stroke. Conclusion: Presence of incidental CMBs was not associated with increased risk for early HT of an ischemic stroke. Interestingly, the prior intake of antiplatelets was found to be protective against HT of ischemic stroke. |
| تدمد: | 0972-2327 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a086cfa123b50e6cfd411685169135eTest https://doi.org/10.4103/0972-2327.194423Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3a086cfa123b50e6cfd411685169135e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09722327 |
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