دورية أكاديمية
Oxidative status parameters in children with urinary tract infection
| العنوان: | Oxidative status parameters in children with urinary tract infection |
|---|---|
| المؤلفون: | Petrovic, Stanislava, Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia, Bogavac-Stanojevic, Natasa, naca@pharmacy.bg.ac.rs, Kotur-Stevuljevic, Jelena, Peco-Antic, Amira, School of Medicine, University of Belgrade, Belgrade, Serbia 3Department of Nephrology, University Children’s Hospital, Belgrade, Serbia, Ivanisevic, Ivana, School of Medicine, University of Belgrade, Belgrade, Serbia, Ivanisevic, Jasmina, Paripovic, Dusan, Department of Nephrology, University Children’s Hospital, Belgrade, Serbia, Jelic-Ivanovic, Zorana |
| المصدر: | Biochemia Medica (editorial_office@biochemia-medica.com); Vol.24 No.2; ISSN 1330-0962 (Print) |
| بيانات النشر: | Medicinska naklada; marketing@medicinskanaklada.hr |
| سنة النشر: | 2014 |
| المجموعة: | Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| مصطلحات موضوعية: | oxidative stress, inflammation, acute kidney injury |
| الوصف: | ntroduction: Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. The aim of this study was to determine the total prooxidant and antioxidant capacity of children with UTI, as well as changes of oxidative status parameters according to acute inflammation persistence and acute kidney injury (AKI) development. Materials and methods: The patients enrolled in the study comprised 50 Caucasian children (median age was 6 months) with UTI. Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), inflammation marker C-reactive protein (CRP) and renal function parameters urea and creatinine were analyzed in patient’s serums. Results: According to duration of inflammation during UTI, TAS values were significantly higher (0.99 vs. 0.58 mmol/L, P = 0.017) and OSI values were significantly lower (0.032 vs. 0.041 AU, P = 0.037) in the subjects with longer duration of inflammation than in the subjects with shorter duration of inflammation. We did not find significant difference in basal values of oxidative status parameters according to AKI development. Conclusions: OSI values could detect the simultaneous change of TAS and TOS due to change in the oxidative-antioxidant balance during the recovery of children with UTI. TAS and OSI as markers of oxidative stress during UTI are sensitive to accompanying inflammatory condition. Further investigations are needed to evaluate whether TAS, TOS and OSI could be used to monitor disease severity in children with UTI. |
| نوع الوثيقة: | text |
| وصف الملف: | |
| اللغة: | English |
| العلاقة: | http://hrcak.srce.hr/125432Test; http://hrcak.srce.hr/file/185284Test |
| الإتاحة: | http://hrcak.srce.hr/125432Test http://hrcak.srce.hr/file/185284Test |
| حقوق: | Full-text papers can be used for personal or educational purposes only. Authors' and publisher's copyrights must be acknowledged. |
| رقم الانضمام: | edsbas.CFCB3002 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |