دورية أكاديمية
Cost-effectiveness analysis of acute kidney injury biomarkers in pediatric cardiac surgery
| العنوان: | Cost-effectiveness analysis of acute kidney injury biomarkers in pediatric cardiac surgery |
|---|---|
| المؤلفون: | Petrovic, Stanislava, Bogavac-Stanojevic, Natasa, Lakic, Dragana, Peco-Antic, Amira, Vulicevic, Irena, Ivanisevic, Ivana, Kotur-Stevuljevic, Jelena, Jelic-Ivanovic, Zorana |
| المصدر: | Biochemia Medica; Vol.25 No.2; ISSN 1330-0962 (Print) |
| بيانات النشر: | Medicinska naklada |
| سنة النشر: | 2015 |
| المجموعة: | Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| مصطلحات موضوعية: | acute kidney injury, cardiac surgery, children, biomarkers, cost effectiveness analysis |
| الوصف: | Introduction: Acute kidney injury (AKI) is significant problem in children with congenital heart disease (CHD) who undergo cardiac surgery. The economic impact of a biomarker-based diagnostic strategy for AKI in pediatric populations undergoing CHD surgery is unknown. The aim of this study was to perform the cost effectiveness analysis of using serum cystatin C (sCysC), urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine liver fatty acid-binding protein (uL-FABP) for the diagnosis of AKI in children after cardiac surgery compared with current diagnostic method (monitoring of serum creatinine (sCr) level). Materials and methods: We developed a decision analytical model to estimate incremental cost-effectiveness of different biomarker-based diagnostic strategies compared to current diagnostic strategy. The Markov model was created to compare the lifetime cost associated with using of sCysC, uNGAL, uL-FABP with monitoring of sCr level for the diagnosis of AKI. The utility measurement included in the analysis was quality-adjusted life years (QALY). The results of the analysis are presented as the incremental cost-effectiveness ratio (ICER). Results: Analysed biomarker-based diagnostic strategies for AKI were cost-effective compared to current diagnostic method. However, uNGAL and sCys C strategies yielded higher costs and lower effectiveness compared to uL-FABP strategy. uL-FABP added 1.43 QALY compared to current diagnostic method at an additional cost of $8521.87 per patient. Therefore, ICER for uL-FABP compared to sCr was $5959.35/QALY. Conclusions: Our results suggest that the use of uL-FABP would represent cost effective strategy for early diagnosis of AKI in children after cardiac surgery. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://hrcak.srce.hr/139813Test; http://hrcak.srce.hr/file/206277Test |
| الإتاحة: | http://hrcak.srce.hr/139813Test http://hrcak.srce.hr/file/206277Test |
| حقوق: | info:eu-repo/semantics/openAccess ; Full-text papers can be used for personal or educational purposes only. Authors' and publisher's copyrights must be acknowledged. |
| رقم الانضمام: | edsbas.F4560D7A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |