Haemoglobin A1c-based screening for prediabetes and diabetes mellitus: a multi-center study in Croatian adult population
| العنوان: | Haemoglobin A1c-based screening for prediabetes and diabetes mellitus: a multi-center study in Croatian adult population |
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| المؤلفون: | Dunja Rogić, Nada Bilopavlović, Ivana Lapić, Dario Rahelić, Blaženka Miškić, Daniela Marasović Krstulović, Hrvoje Pintarić, Ivan Gornik, Milena Krnjaić-Tadijanović, Leida Tandara, Ivanka Ostroški, Mario Štefanović, Fran Smaić, Valentina Cesar Kocijan, Anamarija Đuras, Lada Surjan, Nena Peran, Katarina Kajić, Nora Nikolac Gabaj |
| المصدر: | Biochemia Medica Volume 32 Issue 1 |
| بيانات النشر: | Medicinska naklada, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Glycated Hemoglobin, Male, haemoglobin A1c, Croatia, prevalence, Biochemistry (medical), Clinical Biochemistry, Short Communications, prediabetes, Middle Aged, diabetes mellitus, Prediabetic State, Cross-Sectional Studies, Humans, Mass Screening, Female |
| الوصف: | Introduction Based on the hypothesis that there is a substantial rate of adults with prediabetes and undiagnosed diabetes mellitus (DM), our aim was to perform haemoglobin A1c (HbA1c)-based screening in a cohort of Croatian adults and estimate the prevalence of prediabetes and undiagnosed DM according to American Diabetes Association criteria. Materials and methods This multi-center, cross-sectional study performed in six Croatian hospitals included 5527 patients aged 40 to 70 years admitted to the Emergency Department or undergoing a primary care check-up. Haemoglobin A1c was measured from leftover whole blood samples using the enzymatic method on either Alinity c or Architect c-series analyser (Abbott Laboratories, Chicago, USA). Haemoglobin A1c between 39-47 mmol/mol was classified as prediabetes, while ≥ 48 mmol/mol as undiagnosed DM. Results After exclusion of 435 patients with known DM, the final cohort included 5092 patients (median age 57 ; 56% males). A total of 882 (17.3%) patients had HbA1c values between 39 and 47 mmol/mol. There were 214 (4.2%) patients with HbA1c ≥ 48 mmol/mol. Prediabetes prevalence ranged from 14.2% to 20.5%, while undiagnosed DM from 3.3% to 7.3%, with statistically significant differences among settings (P < 0.001). Age-stratified analysis showed that prediabetes and undiagnosed DM prevalence increase with age (P < 0.001), being 25.4% and 5.8%, respectively, in patients aged 60 to 70 years. Conclusion Underlying impairment of glucose metabolism was identified in about one in five adults, with significant number of patients with already overt DM. These results should serve as a starting point for further steps directed towards promotion of preventive measures for DM in Croatia. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1846-7482 1330-0962 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4defde774ddb1019d2bfae89eb5f42e6Test https://hrcak.srce.hr/file/394938Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4defde774ddb1019d2bfae89eb5f42e6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18467482 13300962 |
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