DIABETIC KETOACIDOSIS ASSOCIATED WITH ANTIPSYCHOTIC DRUGS: CASE REPORTS AND A REVIEW OF LITERATURE
| العنوان: | DIABETIC KETOACIDOSIS ASSOCIATED WITH ANTIPSYCHOTIC DRUGS: CASE REPORTS AND A REVIEW OF LITERATURE |
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| المؤلفون: | Martina Rojnic Kuzman, Antonia Vuk, Maja Baretić, Martina Matovinovic Osvatic |
| المصدر: | Psychiatria Danubina Volume 29 Issue 2 |
| بيانات النشر: | Medicinska naklada, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, Olanzapine, Pediatrics, medicine.medical_specialty, diabetic ketoacidosis, antipsychotics, atypical antipsychotics, risk factors, Adolescent, Diabetic ketoacidosis, medicine.medical_treatment, 030209 endocrinology & metabolism, Diabetic Ketoacidosis, Benzodiazepines, Young Adult, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Insulin, Ziprasidone, Amisulpride, Antipsychotic, Clozapine, second generation antipsychotics, business.industry, General Medicine, Middle Aged, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Psychotic Disorders, Schizophrenia, Haloperidol, Quetiapine, Drug Therapy, Combination, Female, Schizophrenic Psychology, Aripiprazole, business, Antipsychotic Agents, medicine.drug |
| الوصف: | Background Second generation antipsychotics (SGAs) are associated with metabolic disturbances. Diabetic ketoacidosis (DKA) is a rare, but potentially fatal sign of acute glucose metabolism dysregulation linked to the use of SGAs. The aims of this article are to present patients with a history of psychotic disorders and of severe metabolic diabetic ketoacidosis, possibly associated with the use of antipsychotics, and to review the current literature on the topic of antipsychotic-induced DKA. Method PubMed/Medline and EBSCO databases were searched using the keywords: diabetic ketoacidosis, antipsychotics, atypical antipsychotics, second generation antipsychotics, clozapine, olanzapine, risperidone, quetiapine, ziprasidone, aripiprazole, paliperidone, amisulpride and haloperidol. Case reports, case series and reviews of case series were included in the review. Results The majority of patients who developed DKA following treatment with antipsychotics were treated with olanzapine and clozapine in monotherapy or in combination with other antipsychotics. DKA mostly occurred in the first six months of antipsychotic treatment. Other risk factors included insulin resistance prior to antipsychotic treatment, male gender and middle age. Conclusion Clinicians should consider the risk of DKA when starting treatment with SGAs. Preventive measures for patients with psychotic disorders using antipsychotics should include regular assessment of risk factors and screening for diabetes before and after administering antipsychotics, especially in the first months of treatment. Whenever possible, polypharmacy should be avoided. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0353-5053 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4666178c9232e3fb757530bb59c46193Test https://hrcak.srce.hr/184432Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4666178c9232e3fb757530bb59c46193 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03535053 |
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