دورية أكاديمية
High-resolution genome-wide analysis identified recurrent genetic alterations in NK/T-cell lymphoma, nasal type, which are associated with disease progression
| العنوان: | High-resolution genome-wide analysis identified recurrent genetic alterations in NK/T-cell lymphoma, nasal type, which are associated with disease progression |
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| المؤلفون: | Sun, Lin, Li, Min, Huang, Xin, Xu, Jiaosheng, Gao, Zifen, Liu, Cuiling |
| المساهمون: | Liu, CL (reprint author), Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China., Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China., Beijing Childrens Hosp, Dept Dermatol, Beijing 100045, Peoples R China. |
| المصدر: | PubMed ; SCI |
| بيانات النشر: | medical oncology |
| سنة النشر: | 2014 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | Extranodal NK/T-cell lymphoma, nasal type, Array CGH, Genetic alterations, 8p11.23, CONSISTENT PATTERNS, HYBRIDIZATION, LYMPHOMA/LEUKEMIA, TRANSPORTERS, IMMUNITY |
| الوصف: | Extranodal NK/T-cell lymphoma, nasal type, is an aggressive mature NK-cell/T-cell lymphoma. Using array-based comparative genomic hybridization (array CGH) assays, we screened genomic alterations and potential candidate genes implicated in pathogenesis, progression, and prognosis. Our array CGH analysis detected an average of 83 chromosomal aberrations in 13 cases, ranging from 0 to 387. There were 177 recurrent chromosomal gains and 35 recurrent losses. Eleven gains and 14 losses were detected in more than 30 % of the cases, including gains of 3q26.1, 7q34, and 8q24.3 and losses of 15q24.2, 19q13.32, 5p13.2, and 14q21.1. The most common losses were observed in the 15q24.2 and 19q13.32 regions (9 cases, 69.2 %, respectively). Loss of 8p11.23 was associated with significant poor survival (P = 0.024). Five out of six patients with the loss of 8p11.23 died within 8 months after initial diagnosis with a median survival of 6 months. Several candidate genes were identified in the regions with frequent chromosomal aberrations, including ADAM3A (8p11.23) and GSTT1 (22q11.23). In summary, our studies detected recurrent genetic alterations in NK/T-cell lymphoma, some of which are associated with adverse prognosis. Some candidate genes in these regions may be involved in the pathogenesis and disease progression. ; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339003700004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Test ; Oncology ; SCI(E) ; PubMed ; 1 ; ARTICLE ; liucuiling@bjmu.edu.cn ; 7 ; 71 ; 31 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1357-0560 1559-131X |
| العلاقة: | MEDICAL ONCOLOGY.2014,31,(7).; 653330; http://hdl.handle.net/20.500.11897/189363Test; WOS:000339003700004 |
| DOI: | 10.1007/s12032-014-0071-z |
| الإتاحة: | https://doi.org/20.500.11897/189363Test https://doi.org/10.1007/s12032-014-0071-zTest https://hdl.handle.net/20.500.11897/189363Test |
| رقم الانضمام: | edsbas.3CD19D76 |
| قاعدة البيانات: | BASE |
| تدمد: | 13570560 1559131X |
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| DOI: | 10.1007/s12032-014-0071-z |