Metastasis Risk of Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients and Immunocompetent Patients
| العنوان: | Metastasis Risk of Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients and Immunocompetent Patients |
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| المؤلفون: | Elsemieke I. Plasmeijer, E.E. Tromp, Roel E. Genders, Peter O'Rourke, J.N. Bouwes Bavinck, J.A.J. Osinga |
| المصدر: | Acta Dermato-Venereologica, 98(6), 551-555 Acta Dermato-Venereologica, Vol 98, Iss 6, Pp 551-555 (2018) |
| بيانات النشر: | Medical Journals Sweden AB, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Oncology, Skin Neoplasms, Time Factors, Databases, Factual, cutaneous squamous cell carcinoma, cutaneoussquamouscellcarcinoma, medicine.medical_treatment, Rate ratio, Organ transplantation, Metastasis, 030207 dermatology & venereal diseases, 0302 clinical medicine, organtransplantrecipients, Risk Factors, lcsh:Dermatology, organ transplant recipients, Netherlands, Aged, 80 and over, Incidence, Incidence (epidemiology), Immunosuppression, General Medicine, Middle Aged, Tumor Burden, Carcinoma, Squamous Cell, Female, Immunocompetence, Adult, medicine.medical_specialty, Dermatology, Risk Assessment, Immunocompromised Host, 03 medical and health sciences, Internal medicine, medicine, Humans, metastasis, Neoplasm Invasiveness, Risk factor, Aged, Retrospective Studies, business.industry, Organ Transplantation, lcsh:RL1-803, medicine.disease, immunocompetent, Confidence interval, Transplantation, business |
| الوصف: | Organ transplant recipients (OTRs) have a high incidence of cutaneous squamous cell carcinoma (cSCC), and immunosuppression has been reported to be an important risk factor for metastasis. The aim of this study was to identify the metastasis risk over a 10-year period for 593 patients with cSCC, of whom 134 were OTR and 459 were immunocompetent. Metastasis incidence rate was 1,046 (95% confidence interval (95% CI) 524-2,096) per 100,000 person years in OTR and 656 (95% CI; 388-1,107) in immunocompetent patients, yielding an incidence rate ratio of 1.6 (95% CI 0.67-3.81). In OTRs head/neck location, older age at transplantation and older age at diagnosis of first cSCC were associated with metastatic risk, and 7 out of 8 metastasized tumours were smaller than 2 cm. In immunocompetent patients tumour size and tumour depth were associated with metastasis. In conclusion, we were not able to demonstrate an increased incidence rate of metastasis in OTRs compared with immunocompetent patients. However, OTRs and immunocompetent patients differed with regard to risk factors for metastasis. |
| وصف الملف: | application/pdf |
| تدمد: | 0001-5555 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c734defa190e2e3d12dc0f03ebf3907eTest https://doi.org/10.2340/00015555-2901Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c734defa190e2e3d12dc0f03ebf3907e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00015555 |
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