التفاصيل البيبلوغرافية
| العنوان: |
Cost effectiveness of pomalidomide in patients with relapsed and refractory multiple myeloma in Sweden. |
| المؤلفون: |
Borg, Sixten, Nahi, Hareth, Hansson, Markus, Lee, Dawn, Elvidge, Jamie, Persson, Ulf |
| المصدر: |
Acta Oncologica; May2016, Vol. 55 Issue 5, p554-560, 7p |
| مصطلحات موضوعية: |
BORTEZOMIB, COST effectiveness, DRUG resistance in cancer cells, LIFE expectancy, MULTIPLE myeloma, DISEASE relapse, THALIDOMIDE, QUALITY-adjusted life years, DEXAMETHASONE, DESCRIPTIVE statistics, ECONOMICS, PROGNOSIS, THERAPEUTICS |
| مصطلحات جغرافية: |
SWEDEN |
| مستخلص: |
Background: Multiple myeloma (MM) patients who have progressed following treatment with both bortezomib and lenalidomide have a poor prognosis. In this late stage, other effective alternatives are limited, and patients in Sweden are often left with best supportive care. Pomalidomide is a new anti-angiogenic and immunomodulatory drug for the treatment of MM. Our objective was to evaluate the cost effectiveness of pomalidomide as an add-on to best supportive care in patients with relapsed and refractory MM in Sweden. Material and methods: We developed a health-economic discrete event simulation model of a patient’s course through stable disease and progressive disease, until death. It estimates life expectancy, quality-adjusted life years (QALYs) and costs from a societal perspective. Effectiveness data and utilities were taken from the MM-003 trial comparing pomalidomide plus low-dose dexamethasone with high-dose dexamethasone (HIDEX). Cost data were taken from official Swedish price lists, government sources and literature. Results: The model estimates that, if a patient is treated with HIDEX, life expectancy is 1.12 years and the total cost is SEK 179 976 (€19 100), mainly indirect costs. With pomalidomide plus low-dose dexamethasone, life expectancy is 2.33 years, with a total cost of SEK 767 064 (€81 500), mainly in drug and indirect costs. Compared to HIDEX, pomalidomide treatment gives a QALY gain of 0.7351 and an incremental cost of SEK 587 088 (€62 400) consisting of increased drug costs (59%), incremental indirect costs (33%) and other healthcare costs (8%). The incremental cost-effectiveness ratio is SEK 798 613 (€84 900) per QALY gained. Conclusion: In a model of late-stage MM patients with a poor prognosis in the Swedish setting, pomalidomide is associated with a relatively high incremental cost per QALY gained. This model was accepted by the national Swedish reimbursement authority TLV, and pomalidomide was granted reimbursement in Sweden. [ABSTRACT FROM PUBLISHER] |
|
Copyright of Acta Oncologica is the property of Medical Journals Sweden AB and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
