التفاصيل البيبلوغرافية
| العنوان: |
Low-volume grade group 2 prostate cancer candidates for active surveillance: a radical prostatectomy retrospective analysis. |
| المؤلفون: |
Björklund, Johan1,2 (AUTHOR), Cheung, Douglas C.1 (AUTHOR), Martin, Lisa J.1 (AUTHOR), Komisarenko, Maria1 (AUTHOR), Lajkosz, Katharine1 (AUTHOR), Hamilton, Robert J.1 (AUTHOR), Zlotta, Alexandre R.1 (AUTHOR), Finelli, Antonio1 (AUTHOR) |
| المصدر: |
Scandinavian Journal of Urology. Feb- Dec2023, Vol. 57 Issue 1-6, p29-35. 7p. |
| مصطلحات موضوعية: |
*RADICAL prostatectomy, *WATCHFUL waiting, *PROSTATE cancer, *RETROSPECTIVE studies, *PROSTATE biopsy |
| مستخلص: |
Guidelines support considering selected men with ISUP grade group (GG) 2 prostate cancer for active surveillance (AS). We assessed the association of clinical variables with unfavorable pathology at radical prostatectomy in low-volume GG 2 prostate cancer on biopsy in a retrospective cohort. This was a retrospective analysis of 378 men with low-volume (≤ 2 cores) GG 2 localized prostate cancer who underwent prostatectomy at a single tertiary cancer center. Multivariable logistic regression of unfavorable pathology, upgrading to ≥ T3, or GG ≥ 3 was performed in relation to clinical factors, common variables used in AS in GG 1 and percentage Gleason 4 at biopsy. We compared the performance of potential variables with commonly used combined AS restrictions in GG 1 prostate cancer. In total, 128/378 (34%) men had unfavorable pathology at radical prostatectomy. On multivariable analysis, > 5% Gleason pattern 4 was independently associated with an increased risk of GG ≥ 3. A maximum percentage core involvement > 50% was independently associated with an increased risk of pT-stage ≥ 3 and unfavorable pathology. Restriction to patients with ≤ 5% Gleason 4 decreased the upgrading of both unfavorable pathology (OR = 0.62, p = 0.041) and GG ≥ 3 (OR = 0.17, p = 0.0007) compared to the full cohort, while restriction to those with ≤ 50% of max core involvement did not. In low-volume GG 2, the percentage of Gleason 4 of ≤ 5% was the strongest predictor in reducing upgrading at final pathology. This easily available pathological descriptor could be used to guide urologists and patients when considering AS in this setting. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder