دورية أكاديمية
Chemical Compositions of Lianqiao (Forsythia suspensa) Extracts and Their Potential Health Benefits
| العنوان: | Chemical Compositions of Lianqiao (Forsythia suspensa) Extracts and Their Potential Health Benefits |
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| المؤلفون: | Boyan Gao, Hanshu Zhu, Zhihao Liu, Xiaohua He, Jianghao Sun, Yanfang Li, Xianli Wu, Pamela Pehrsson, Yaqiong Zhang, Yuanhang Yao, Liangli Yu |
| المصدر: | Pharmaceuticals, Vol 17, Iss 6, p 740 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | HPLC-MS/MS, radical scavenging, COVID-19, SARS-CoV-2 virus spike protein, ACE2, Forsythia suspensa (Lianqiao), Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | This study evaluated the fruits of Forsythia suspensa (Lianqiao), an important economic crop, for the chemical components of its water and ethanol extracts, inhibitory effects on SARS-CoV-2 virus spike protein binding to ACE2, inhibition of ACE2 activity, and capacity to scavenge free radicals. A total of 42 compounds were tentatively identified in the extracts via HPLC-MS/MS analysis. The water extract showed a greater ACE2 inhibition but a weaker inhibition on SARS-CoV-2 spike protein binding to ACE2 than the ethanol extract on a per-botanical-weight-concentration basis. The phenolic content was found to be greater in the water extract at 45.19 mg GAE/g dry botanical weight than in the ethanol extract (6.89 mg GAE/g dry botanical). Furthermore, the water extract had greater scavenging capacities against HO●, DPPH●, and ABTS●+ at 448.48, 66.36, and 121.29 µmol TE/g dry botanical, respectively, as compared to that of the ethanol extract (154.04, 3.55, and 33.83 µmol TE/g dry botanical, respectively). These results warrant further research into, and the development of, the potential COVID-19-preventive applications of Lianqiao and its extracts. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8247 |
| العلاقة: | https://www.mdpi.com/1424-8247/17/6/740Test; https://doaj.org/toc/1424-8247Test |
| DOI: | 10.3390/ph17060740 |
| الوصول الحر: | https://doaj.org/article/e039ea8032a74454823996efca259777Test |
| رقم الانضمام: | edsdoj.039ea8032a74454823996efca259777 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14248247 |
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| DOI: | 10.3390/ph17060740 |