The Evolving Landscape of Biomarkers for Anti-PD-1 or Anti-PD-L1 Therapy
| العنوان: | The Evolving Landscape of Biomarkers for Anti-PD-1 or Anti-PD-L1 Therapy |
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| المؤلفون: | Tunger, Antje, Sommer, Ulrich, Wehner, Rebekka, Kubasch, Anne Sophie, Grimm, Marc-Oliver, Bachmann, Michael Philipp, Platzbecker, Uwe, Bornhäuser, Martin, Baretton, Gustavo, Schmitz, Marc |
| المصدر: | Journal of Clinical Medicine, Vol 8, Iss 10, p 1534 (2019) Journal of Clinical Medicine 8(2019)10, 1534 Journal of Clinical Medicine |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | cancer immunotherapy, immune monitoring, lcsh:R, lcsh:Medicine, ddc:610, immune checkpoints, programmed cell death protein 1, programmed cell death 1 ligand 1, Review |
| الوصف: | The administration of antibodies blocking the immune checkpoint molecules programmed cell death protein 1 (PD-1) or programmed cell death 1 ligand 1 (PD-L1) has evolved as a very promising treatment option for cancer patients. PD-1/PD-L1 inhibition has significantly enhanced expansion, cytokine secretion, and cytotoxic activity of CD4+ and CD8+ T lymphocytes, resulting in enhanced antitumor responses. Anti-PD-1 or anti-PD-L1 therapy has induced tumor regression and improved clinical outcome in patients with different tumor entities, including melanoma, non-small-cell lung cancer, and renal cell carcinoma. These findings led to the approval of various anti-PD-1 or anti-PD-L1 antibodies for the treatment of tumor patients. However, the majority of patients have failed to respond to this treatment modality. Comprehensive immune monitoring of clinical trials led to the identification of potential biomarkers distinguishing between responders and non-responders, the discovery of modes of treatment resistance, and the design of improved immunotherapeutic strategies. In this review article, we summarize the evolving landscape of biomarkers for anti-PD-1 or anti-PD-L1 therapy. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2077-0383 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::36020e29f5ea2689d26a28c585007bf4Test https://www.mdpi.com/2077-0383/8/10/1534Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....36020e29f5ea2689d26a28c585007bf4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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