Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis
| العنوان: | Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis |
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| المؤلفون: | Rosa Zampino, Domenico Iossa, Maria Paola Ursi, Lorenzo Bertolino, Arta Karruli, Rosa Molaro, Gennaro Esposito, Martina Vitrone, Fabiana D’Amico, Rosina Albisinni, Emanuele Durante-Mangoni, on behalf of the Monaldi Hospital CardiovascularInfection Group |
| المساهمون: | Zampino, R., Iossa, D., Ursi, M. P., Bertolino, L., Karruli, A., Molaro, R., Esposito, G., Vitrone, M., D'Amico, F., Albisinni, R., Durante-Mangoni, E. |
| المصدر: | Journal of Clinical Medicine, Vol 10, Iss 5386, p 5386 (2021) Journal of Clinical Medicine Volume 10 Issue 22 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Homocysteine, D-dimers, Fibrinogen, Gastroenterology, embolism, Article, chemistry.chemical_compound, Internal medicine, medicine, Clinical significance, Prothrombin time, medicine.diagnostic_test, business.industry, aPTT, biomarkers, General Medicine, Biomarker, medicine.disease, chemistry, Embolism, Hemostasis, Infective endocarditis, D-dimer, Medicine, prognosis, business, Partial thromboplastin time, medicine.drug, circulatory and respiratory physiology |
| الوصف: | (1) Background: The aim of this study was to assess the clinical significance and prognostic role of the main hemostasis parameters in infective endocarditis (IE): prothrombin time as international normalized ratio (PT-INR), activated partial thromboplastin time (aPTT), fibrinogen, D-dimers, platelet count, homocysteine. (2) Methods: We studied 337 patients with IE. Clinical, hemato-chemical and echocardiography parameters were analyzed. Coagulation parameters were measured on admission. (3) Results: D-dimers levels (p = 0.012) and a prolonged PT-INR (p = 0.013) were associated with higher in-hospital mortality, while prolonged aPTT (p = 0.021) was associated with increased 1-year mortality. Staphylococcus aureus (S. aureus) infection (p = 0.003), prosthetic valve endocarditis (PVE) (p = 0.001), surgical indication (p = 0.002) and higher D-dimer levels (p = 0.005) were independent predictors of in-hospital mortality. PVE (p = 0.001), a higher Charlson Comorbidity Index (p = 0.049), surgical indication (p = 0.001) and prolonged aPTT (p = 0.012) were independent predictors of 1-year mortality. Higher levels of D-dimers (p < 0.001) and a shorter aPTT (p < 0.001) were associated with embolic complications of IE. S. aureus etiology was bound to higher D-dimers levels (p < 0.001) and a shorter aPTT (p = 0.006). (4) Conclusions: Elevated D-dimers are associated with a higher risk for in-hospital mortality in IE patients. High D-dimers and a short aPTT are associated with a higher risk for embolic events in IE. A longer aPTT is associated with 1-year mortality. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2077-0383 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2177579dd3f4b567ba6b3e1304beed70Test https://www.mdpi.com/2077-0383/10/22/5386Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2177579dd3f4b567ba6b3e1304beed70 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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