دورية أكاديمية
Galectin-3 performance in histologic and cytologic assessment of thyroid nodules. A systematic review and meta-analysis
| العنوان: | Galectin-3 performance in histologic and cytologic assessment of thyroid nodules. A systematic review and meta-analysis |
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| المؤلفون: | Trimboli, Pierpaolo, Virili, Camilla, Romanelli, Francesco, Crescenzi, Anna, Giovanella, Luca |
| المساهمون: | Trimboli, Pierpaolo, Virili, Camilla, Romanelli, Francesco, Crescenzi, Anna, Giovanella, Luca |
| بيانات النشر: | MDPI AG Basel |
| سنة النشر: | 2017 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | cytology, fine needle aspiration (FNAC), galectin-3, meta-analysi, thyroid cancer, biomarkers, tumor, carcinoma, galectin 3, human, thyroid neoplasm, catalysi, Molecular Biology, Spectroscopy, computer science applications1707 computer vision and pattern recognition, physical and theoretical chemistry, organic chemistry, inorganic chemistry |
| الوصف: | The literature on Galectin-3 (Gal-3) was systematically reviewed to achieve more robust information on its histologic reliability in identifying thyroid cancers and on the concordance between Gal-3 test in histologic and cytologic samples. A computer search of the PubMed and Scopus databases was conducted by combinations of the terms thyroid and Gal-3. Initially, 545 articles were found and, after their critical review, 52 original papers were finally included. They reported 8172 nodules with histologic evaluation of Gal-3, of which 358 with also preoperative FNAC Gal-3 assessment. At histology, Gal-3 sensitivity was 87% (95% confidence intervals [CI] from 86% to 88%), and specificity 87% (95% CI from 86% to 88%); in both cases, we found heterogeneity (I285% and 93%, respectively) and significant publication bias (p < 0.001). The pooled rate of positive Gal-3 at fine needle aspiration (FNAC) among cancers with histologically proven Gal-3 positivity was 94% (95% CI from 89% to 97%), with neither heterogeneity (I214.5%) nor bias (p = 0.086). These data show high reliability of Gal-3 for thyroid cancer at histology, while its sensitivity on FNAC samples is lower. The limits of cytologic preparations and interpretation of Gal-3 results have to be solved. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/28800068; info:eu-repo/semantics/altIdentifier/wos/WOS:000408897400157; volume:18; issue:8; numberofpages:11; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/11573/1110672Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85027253324 |
| DOI: | 10.3390/ijms18081756 |
| الإتاحة: | https://doi.org/10.3390/ijms18081756Test http://hdl.handle.net/11573/1110672Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9172B26C |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms18081756 |
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