Selective Synthesis of N-Acylnortropane Derivatives in Palladium-Catalysed Aminocarbonylation
| العنوان: | Selective Synthesis of N-Acylnortropane Derivatives in Palladium-Catalysed Aminocarbonylation |
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| المؤلفون: | Haroon Rasheed, Attila Takács, Ádám Erdélyi, László Kollár |
| المصدر: | Molecules, Vol 26, Iss 1813, p 1813 (2021) Molecules Volume 26 Issue 6 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Xantphos, Nortropanes, Pharmaceutical Science, chemistry.chemical_element, N-acylnortropanes, Medicinal chemistry, Article, Catalysis, carbon monoxide, Analytical Chemistry, lcsh:QD241-441, chemistry.chemical_compound, Nucleophile, lcsh:Organic chemistry, Amide, Drug Discovery, Physical and Theoretical Chemistry, Octane, Molecular Structure, aminocarbonylation, Chemistry, Aryl, Organic Chemistry, Tropane, palladium, Chemistry (miscellaneous), Molecular Medicine, Palladium |
| الوصف: | The aminocarbonylation of various alkenyl and (hetero)aryl iodides was carried out using tropane-based amines of biological importance, such as 8-azabicyclo[3.2.1]octan-3-one (nortropinone) and 3α-hydroxy-8-azabicyclo[3.2.1]octane (nortropine) as N-nucleophile. Using iodoalkenes, the two nucleophiles were selectively converted to the corresponding amide in the presence of Pd(OAc)2/2 PPh3 catalysts. In the presence of several iodo(hetero)arenes, the application of the bidentate Xantphos was necessary to produce the target compounds selectively. The new carboxamides of varied structure, formed in palladium-catalyzed aminocarbonylation reactions, were isolated and fully characterized. In this way, a novel synthetic method has been developed for the producing of N-acylnortropane derivatives of biological importance. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49de3f8821a958bab22194b49d4ef60Test https://www.mdpi.com/1420-3049/26/6/1813Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e49de3f8821a958bab22194b49d4ef60 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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