دورية أكاديمية
Licensing Natural Killers for Antiviral Immunity
| العنوان: | Licensing Natural Killers for Antiviral Immunity |
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| المؤلفون: | John M. Cronk, Eleni Fafoutis, Michael G. Brown |
| المصدر: | Pathogens, Vol 10, Iss 908, p 908 (2021) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | iKIR, Ly49, self-MHC I, antiviral immunity, polymorphism, missing-self, Medicine |
| الوصف: | Immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors (IRs) enable discrimination between self- and non-self molecules on the surface of host target cells. In this regard, they have a vital role in self-tolerance through binding and activating intracellular tyrosine phosphatases which can inhibit cellular activation. Yet, self-MHC class I (MHC I)-specific IRs are versatile in that they can also positively impact lymphocyte functionality, as exemplified by their role in natural killer (NK) cell education, often referred to as ’licensing‘. Recent discoveries using defined mouse models of cytomegalovirus (CMV) infection have revealed that select self-MHC I IRs can increase NK cell antiviral defenses as well, whereas other licensing IRs cannot, or instead impede virus-specific NK responses for reasons that remain poorly understood. This review highlights a role for self-MHC I ‘licensing’ IRs in antiviral immunity, especially in the context of CMV infection, their impact on virus-specific NK cells during acute infection, and their potential to affect viral pathogenesis and disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2076-0817 |
| العلاقة: | https://www.mdpi.com/2076-0817/10/7/908Test; https://doaj.org/toc/2076-0817Test; https://doaj.org/article/8670ffab9a714890b9eb9aad60559ff6Test |
| DOI: | 10.3390/pathogens10070908 |
| الإتاحة: | https://doi.org/10.3390/pathogens10070908Test https://doaj.org/article/8670ffab9a714890b9eb9aad60559ff6Test |
| رقم الانضمام: | edsbas.F6DEAA85 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20760817 |
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| DOI: | 10.3390/pathogens10070908 |