دورية أكاديمية
Thiotepa, Busulfan, Cyclophosphamide: Effective but Toxic Conditioning Regimen Prior to Autologous Hematopoietic Stem Cell Transplantation in Central Nervous System Lymphoma
| العنوان: | Thiotepa, Busulfan, Cyclophosphamide: Effective but Toxic Conditioning Regimen Prior to Autologous Hematopoietic Stem Cell Transplantation in Central Nervous System Lymphoma |
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| المؤلفون: | Lebon Delphine, Debureaux Pierre-Edouard, Royer Bruno, Gruson Bérengère, Joris Magalie, Votte Patrick, Marolleau Jean-Pierre, Morel Pierre |
| المصدر: | Medical Sciences, Vol 11, Iss 1, p 14 (2023) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | autologous hematopoietic stem cell transplantation, central nervous system lymphoma, infections, conditioning, adverse events, Medicine |
| الوصف: | In primary central nervous system lymphoma, two-year progression-free survival rates of up to 63 percent have been reported for first-line autologous stem cell transplantation after conditioning with the thiotepa busulfan cyclophosphamide regimen. However, 11 percent of the patients died due to toxicity. Besides conventional survival, progression-free survival and treatment related mortality analyses, a competing-risk analysis was applied to our cohort of twenty-four consecutive patients with primary or secondary central nervous system lymphoma who underwent autologous stem cell transplantation after thiotepa busulfan cyclophosphamide conditioning. The two-year overall survival and progression-free survival rates were 78 percent and 65 percent, respectively. The treatment-related mortality rate was 21 percent. The competing risks analysis demonstrate that age 60 or over and the infusion of less than 4.6 × 106/kg CD34+ stem cells were significant adverse prognostic factors for overall survival. Autologous stem cell transplantation with thiotepa busulfan cyclophosphamide conditioning was associated with sustained remission and survival. Nevertheless, the intensive thiotepa busulfan cyclophosphamide conditioning regimen was highly toxic, especially in older patients. Thus, our results suggest that future studies should aim at identifying the subgroup of patients who will really benefit of the procedure and/or to reduce the toxicity of future conditioning regimen. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2076-3271 |
| العلاقة: | https://www.mdpi.com/2076-3271/11/1/14Test; https://doaj.org/toc/2076-3271Test; https://doaj.org/article/d6197d846f544837b5d1cda6a6460afaTest |
| DOI: | 10.3390/medsci11010014 |
| الإتاحة: | https://doi.org/10.3390/medsci11010014Test https://doaj.org/article/d6197d846f544837b5d1cda6a6460afaTest |
| رقم الانضمام: | edsbas.187FC672 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20763271 |
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| DOI: | 10.3390/medsci11010014 |