دورية أكاديمية
The P2X7 Receptor in Autoimmunity
| العنوان: | The P2X7 Receptor in Autoimmunity |
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| المؤلفون: | Fabio Grassi, Gaia Salina |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 18, p 14116 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | purinergic signaling, autoimmunity, autoantibodies, T cells, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The P2X7 receptor (P2X7R) is an ATP-gated nonselective cationic channel that, upon intense stimulation, can progress to the opening of a pore permeable to molecules up to 900 Da. Apart from its broad expression in cells of the innate and adaptive immune systems, it is expressed in multiple cell types in different tissues. The dual gating property of P2X7R is instrumental in determining cellular responses, which depend on the expression level of the receptor, timing of stimulation, and microenvironmental cues, thus often complicating the interpretation of experimental data in comprehensive settings. Here we review the existing literature on P2X7R activity in autoimmunity, pinpointing the different functions in cells involved in the immunopathological processes that can make it difficult to model as a druggable target. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/24/18/14116Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms241814116 |
| الوصول الحر: | https://doaj.org/article/81d370026c924e1a8f36b8bf76d3cd87Test |
| رقم الانضمام: | edsdoj.81d370026c924e1a8f36b8bf76d3cd87 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms241814116 |