دورية أكاديمية
Oral Pharmacokinetics of a Chitosan-Based Nano- Drug Delivery System of Interferon Alpha
| العنوان: | Oral Pharmacokinetics of a Chitosan-Based Nano- Drug Delivery System of Interferon Alpha |
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| المؤلفون: | Imperiale, Julieta Celeste, Schlachet, Inbar, Lewicki, Marianela, Sosnik, Alejandro Dario, Biglione, Mirna Marcela |
| بيانات النشر: | MDPI AG |
| المجموعة: | CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: | IFNΑ, IN VITRO INTESTINAL PERMEABILITY, ORAL PHARMACOKINETICS, ORAL PROTEIN DELIVERY, POLYMERIC NANOPARTICLES, https://purl.org/becyt/ford/2.10Test, https://purl.org/becyt/ford/2Test |
| الوصف: | Interferon alpha (IFN) is a protein drug used to treat viral infections and cancer diseases. Dueto its poor stability in the gastrointestinal tract, only parenteral administration ensures bioavailability,which is associated with severe side eects. We hypothesized that the nanoencapsulation ofIFN within nanoparticles of the mucoadhesive polysaccharide chitosan would improve theoral bioavailability of this drug. In this work, we produced IFN-loaded chitosan nanoparticlesby the ionotropic gelation method. Their hydrodynamic diameter, polydispersity index andconcentration were characterized by dynamic light scattering and nanoparticle tracking analysis.After confirming their good cell compatibility in Caco-2 and WISH cells, the permeability ofunmodified and poly(ethylene glycol) (PEG)-modified (PEGylated) nanoparticles was measured inmonoculture (Caco-2) and co-culture (Caco-2/HT29-MTX) cell monolayers. Results indicated thatthe nanoparticles cross the intestinal epithelium mainly by the paracellular route. Finally, the studyof the oral pharmacokinetics of nanoencapsulated IFN in BalbC mice revealed two maxima andarea-under-the-curve of 56.9 pg*h/mL. ; Fil: Imperiale, Julieta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina ; Fil: Schlachet, Inbar. Technion - Israel Institute of Technology; Israel ; Fil: Lewicki, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina ; Fil: Sosnik, Alejandro Dario. Technion - Israel Institute of Technology; Israel ; Fil: Biglione, Mirna Marcela. Consejo Nacional de Investigaciones ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2073-4360 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4360/11/11/1862Test; http://hdl.handle.net/11336/122998Test; Imperiale, Julieta Celeste; Schlachet, Inbar; Lewicki, Marianela; Sosnik, Alejandro Dario; Biglione, Mirna Marcela; Oral Pharmacokinetics of a Chitosan-Based Nano- Drug Delivery System of Interferon Alpha; MDPI AG; Polymers; 11; 11; 11-2019; 1-13; CONICET Digital; CONICET |
| الإتاحة: | https://doi.org/10.3390/polym11111862Test http://hdl.handle.net/11336/122998Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-sa/2.5/arTest/ |
| رقم الانضمام: | edsbas.D951F8A |
| قاعدة البيانات: | BASE |
| تدمد: | 20734360 |
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