دورية أكاديمية
Drug Design Targeting the Muscarinic Receptors and the Implications in Central Nervous System Disorders
| العنوان: | Drug Design Targeting the Muscarinic Receptors and the Implications in Central Nervous System Disorders |
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| المؤلفون: | Johnson, Chad R., Kangas, Brian D., Jutkiewicz, Emily M., Bergman, Jack, Coop, Andrew |
| المصدر: | Biomedicines ; 10 ; 2 |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2022 |
| المجموعة: | UMB Digital Archive (University of Maryland, Baltimore) |
| مصطلحات موضوعية: | Alzheimer’s disease, Depression, Drug design, Major depressive disorder, Muscarinic agonist, Muscarinic antagonist, Muscarinic receptors, Positive allosteric modulator, Schizophrenia |
| الوصف: | There is substantial evidence that cholinergic system function impairment plays a significant role in many central nervous system (CNS) disorders. During the past three decades, muscarinic receptors (mAChRs) have been implicated in various pathologies and have been prominent targets of drug-design efforts. However, due to the high sequence homology of the orthosteric binding site, many drug candidates resulted in limited clinical success. Although several advances in treating peripheral pathologies have been achieved, targeting CNS pathologies remains challenging for researchers. Nevertheless, significant progress has been made in recent years to develop functionally selective orthosteric and allosteric ligands targeting the mAChRs with limited side effect profiles. This review highlights past efforts and focuses on recent advances in drug design targeting these receptors for Alzheimer’s disease (AD), schizophrenia (SZ), and depression. © 2022 by the authors. ; National Institute of Mental Health ; https://doi.org/10.3390/biomedicines10020398Test |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Biomedicines; http://hdl.handle.net/10713/18039Test |
| DOI: | 10.3390/biomedicines10020398 |
| الإتاحة: | https://doi.org/10.3390/biomedicines10020398Test http://hdl.handle.net/10713/18039Test |
| رقم الانضمام: | edsbas.D9B1F4AD |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/biomedicines10020398 |
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