Pathobiologic Roles of Epstein–Barr Virus-Encoded MicroRNAs in Human Lymphomas
| العنوان: | Pathobiologic Roles of Epstein–Barr Virus-Encoded MicroRNAs in Human Lymphomas |
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| المؤلفون: | Mohsen Navari, Lorenzo Leoncini, Pier Paolo Piccaluga, Maryam Etebari, Mostafa Ibrahimi |
| المساهمون: | Navari, Mohsen, Etebari, Maryam, Ibrahimi, Mostafa, Leoncini, Lorenzo, Piccaluga, Pier Paolo |
| المصدر: | International Journal of Molecular Sciences, Vol 19, Iss 4, p 1168 (2018) International Journal of Molecular Sciences |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Lymphoma, Bam HI fragment H rightward open reading frame 1, BamHI-A rightward transcript, BART, BHRF1, Epstein–Barr Virus, Human lymphoma, MicroRNA, Catalysis, Molecular Biology, Spectroscopy, Computer Science Applications1707 Computer Vision and Pattern Recognition, Physical and Theoretical Chemistry, Organic Chemistry, Inorganic Chemistry, human lymphoma, Review, Exosomes, medicine.disease_cause, lcsh:Chemistry, Epstein-Barr Virus Infection, hemic and lymphatic diseases, Virus latency, lcsh:QH301-705.5, microRNA, General Medicine, Virus Latency, Computer Science Applications, Immunosurveillance, RNA, Viral, Human, Gene Expression Regulation, Viral, Biology, Epstein–Barr Viru, Virus, 03 medical and health sciences, medicine, Humans, Epstein–Barr virus infection, medicine.disease, Epstein–Barr virus, Microvesicles, Exosome, MicroRNAs, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Cancer research |
| الوصف: | Epstein-Barr virus (EBV) is a human γ-herpesvirus implicated in several human malignancies, including a wide range of lymphomas. Several molecules encoded by EBV in its latent state are believed to be related to EBV-induced lymphomagenesis, among which microRNAs-small RNAs with a posttranscriptional regulating role-are of great importance. The genome of EBV encodes 44 mature microRNAs belonging to two different classes, including BamHI-A rightward transcript (BART) and Bam HI fragment H rightward open reading frame 1 (BHRF1), with different expression levels in different EBV latency types. These microRNAs might contribute to the pathogenetic effects exerted by EBV through targeting self mRNAs and host mRNAs and interfering with several important cellular mechanisms such as immunosurveillance, cell proliferation, and apoptosis. In addition, EBV microRNAs can regulate the surrounding microenvironment of the infected cells through exosomal transportation. Moreover, these small molecules could be potentially used as molecular markers. In this review, we try to present an updated and extensive view of the role of EBV-encoded miRNAs in human lymphomas. |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc8b950aedcfa590d899d3ee5ae130aTest http://www.mdpi.com/1422-0067/19/4/1168Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5fc8b950aedcfa590d899d3ee5ae130a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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