Non-Steroidal Anti-Inflammatory Drugs in the Carcinogenesis of the Gastrointestinal Tract
| العنوان: | Non-Steroidal Anti-Inflammatory Drugs in the Carcinogenesis of the Gastrointestinal Tract |
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| المؤلفون: | Debora Compare, Gerardo Nardone, Olga Maria Nardone |
| المساهمون: | Compare, Debora, O. M., Nardone, Nardone, GERARDO ANTONIO PIO |
| المصدر: | Pharmaceuticals, Vol 3, Iss 8, Pp 2495-2516 (2010) Pharmaceuticals |
| بيانات النشر: | MDPI AG, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Angiogenesis, Colorectal cancer, DNA damage, Esophageal cancer, lcsh:Medicine, lcsh:RS1-441, Pharmaceutical Science, Inflammation, Review, medicine.disease_cause, Non-Steroidal Anti-Inflammatory Drug, lcsh:Pharmacy and materia medica, Drug Discovery, medicine, non-steroidal anti-inflammatory drugs, Cancer prevention, biology, business.industry, lcsh:R, Cancer, medicine.disease, cyclooxygenase-2, Immunology, biology.protein, Molecular Medicine, Cyclooxygenase, medicine.symptom, Gastric cancer, business, Carcinogenesis |
| الوصف: | It is estimated that underlying infections and inflammatory responses are linked to 15-20% of all deaths from cancer worldwide. Inflammation is a physiologic process in response to tissue damage resulting from microbial pathogen infection, chemical irritation, and/or wounding. Tissues injured throughout the recruitment of inflammatory cells such as macrophages and neutrophils, generate a great amount of growth factors, cytokines, and reactive oxygen and nitrogen species that may cause DNA damage that in turn predisposes to the transformation from chronic inflammation to neoplasia. Cyclooxygenase (COX), playing a key role in cell homeostasis, angiogenesis and tumourigenesis, may represent the link between inflammation and cancer. Currently COX is becoming a pharmacological target for cancer prevention and treatment.It is estimated that underlying infections and inflammatory responses are linked to 15-20% of all deaths from cancer worldwide. Inflammation is a physiologic process in response to tissue damage resulting from microbial pathogen infection, chemical irritation, and/or wounding. Tissues injured throughout the recruitment of inflammatory cells such as macrophages and neutrophils, generate a great amount of growth factors, cytokines, and reactive oxygen and nitrogen species that may cause DNA damage that in turn predisposes to the transformation from chronic inflammation to neoplasia. Cyclooxygenase (COX), playing a key role in cell homeostasis, angiogenesis and tumourigenesis, may represent the link between inflammation and cancer. Currently COX is becoming a pharmacological target for cancer prevention and treatment. |
| وصف الملف: | ELETTRONICO |
| تدمد: | 1424-8247 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e67ab3be78ee0427a1616c6e54258aTest https://doi.org/10.3390/ph3082495Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....61e67ab3be78ee0427a1616c6e54258a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14248247 |
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