Gallic Acid Alleviates Hypertriglyceridemia and Fat Accumulation via Modulating Glycolysis and Lipolysis Pathways in Perirenal Adipose Tissues of Rats Fed a High-Fructose Diet
| العنوان: | Gallic Acid Alleviates Hypertriglyceridemia and Fat Accumulation via Modulating Glycolysis and Lipolysis Pathways in Perirenal Adipose Tissues of Rats Fed a High-Fructose Diet |
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| المؤلفون: | Wen Chang Chang, Da Wei Huang, James Swi Bea Wu, Heng Jui Yang, Szu Chuan Shen |
| المصدر: | International Journal of Molecular Sciences, Vol 19, Iss 1, p 254 (2018) International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 19; Issue 1; Pages: 254 |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_treatment, Adipose tissue, lcsh:Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Insulin, lcsh:QH301-705.5, Spectroscopy, Adiposity, biology, Chemistry, General Medicine, Computer Science Applications, Adipose Tissue, 030220 oncology & carcinogenesis, Carbohydrate Metabolism, gallic acid, Glycolysis, Metabolic Networks and Pathways, Signal Transduction, medicine.medical_specialty, Lipolysis, hypertriglyceridemia, high-fructose diet, insulin signaling, fat accumulation, Fructose, Carbohydrate metabolism, Diet, High-Fat, Article, Catalysis, Diabetes Mellitus, Experimental, Inorganic Chemistry, 03 medical and health sciences, Internal medicine, medicine, Animals, Physical and Theoretical Chemistry, Molecular Biology, Triglyceride, Organic Chemistry, Hypertriglyceridemia, nutritional and metabolic diseases, Lipid Metabolism, medicine.disease, Rats, Disease Models, Animal, 030104 developmental biology, Endocrinology, lcsh:Biology (General), lcsh:QD1-999, Adipose triglyceride lipase, biology.protein, Energy Metabolism, GLUT4 |
| الوصف: | This study investigated the ameliorative effect of gallic acid (GA) on hypertriglyceridemia and fat accumulation in perirenal adipose tissues of high-fructose diet (HFD)-induced diabetic rats. The previous results showed that orally administered GA (30 mg/kg body weight) for four weeks significantly reduced the levels of plasma glucose and triglyceride (TG) in HFD rats. GA also markedly decreased the perirenal adipose tissues weight of HFD rats in present study (p < 0.05). Western blot assay indicated that GA restored expression of insulin signaling-related proteins, such as insulin receptor (IR), protein kinase C-zeta (PKC-ζ), and glucose transporter-4 (GLUT4) in the perirenal adipose tissues of HFD rats. Moreover, GA enhanced expression of glycolysis-related proteins, such as phosphofructokinase (PFK) and pyruvate kinase (PK), and increased the expression of lipolysis-related proteins, such as adipose triglyceride lipase (ATGL), which is involved in lipolysis in the perirenal adipose tissues of HFD rats. This study revealed that GA may alleviate hypertriglyceridemia and fat accumulation through enhancing glycolysis and lipolysis pathways in perirenal adipose tissues of HFD rats. These findings also suggest the potential of GA in preventing the progression of diabetes mellitus (DM) complications. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ac2647b54266ea2ca2e6670b65f072Test http://www.mdpi.com/1422-0067/19/1/254Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a6ac2647b54266ea2ca2e6670b65f072 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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