Bare Metal Stents on Resveratrol-Coated Balloons in Porcine Coronary and Peripheral Arteries
| العنوان: | Bare Metal Stents on Resveratrol-Coated Balloons in Porcine Coronary and Peripheral Arteries |
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| المؤلفون: | Stefanie Kamann, Tobias Haase, Nicola Stolzenburg, Melanie Löchel, Daniel Peters-Berg, Denise Schütt, Jörg Schnorr |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13099 International Journal of Molecular Sciences, Vol 22, Iss 13099, p 13099 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | QH301-705.5, Swine, resveratrol, Article, Catalysis, Inorganic Chemistry, restenosis, Neointima, Animals, Biology (General), drug-coated balloon catheter, Physical and Theoretical Chemistry, QD1-999, Molecular Biology, Spectroscopy, Fibrin, Wound Healing, stent implantation, Vasa Vasorum, Organic Chemistry, Drug-Eluting Stents, Equipment Design, vascular healing, General Medicine, Coronary Vessels, Computer Science Applications, Chemistry, Disease Models, Animal, neovascularization, Feasibility Studies, Angioplasty, Balloon |
| الوصف: | Balloon angioplasty and stent implantation are standard techniques to reopen stenotic vessels. Often, balloons or stents coated with cytostatic drugs are used to prevent re-occlusion of the arteries. Resveratrol, which is known for its numerous beneficial effects on cardiovascular health, is used as an antioxidant additive on paclitaxel-coated balloon catheters. What is still unclear is whether resveratrol-only balloon coating in combination with a bare metal stent (BMS) also has positive effects on vascular healing. Here, we analyzed neointimal thickening, fibrin deposition, inflammation, vasa vasorum density, and reendothelialization after implantation of BMS via a resveratrol coated balloon approach in a porcine model. In general, resveratrol treatment did not result in significantly altered responses compared to the control group in peripheral arteries. In coronary arteries, an increase in vasa vasorum density became evident three days after resveratrol treatment compared to the control group and abolished up to day 7. Significant effects of the resveratrol treatment on the fibrin score or intima-media area were transient and restricted to either peripheral or coronary arteries. In conclusion, local single-dose resveratrol treatment via a resveratrol-only coated balloon and BMS approach did not lead to adverse systemic or local effects, but also no significant beneficial effects on vascular healing were detected in the current study. |
| وصف الملف: | application/pdf |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2b6e357bde82b15eb501b352d675d5Test https://doi.org/10.3390/ijms222313099Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fd2b6e357bde82b15eb501b352d675d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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