دورية أكاديمية
In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies
العنوان: | In Vitro Effects of Methylprednisolone over Oligodendroglial Cells: Foresight to Future Cell Therapies |
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المؤلفون: | Ulises Gómez-Pinedo, Jordi A. Matías-Guiu, Denise Ojeda-Hernandez, Sarah de la Fuente-Martin, Ola Mohamed-Fathy Kamal, Maria Soledad Benito-Martin, Belen Selma-Calvo, Paloma Montero-Escribano, Jorge Matías-Guiu |
المصدر: | Cells, Vol 12, Iss 11, p 1515 (2023) |
بيانات النشر: | MDPI AG |
سنة النشر: | 2023 |
المجموعة: | Directory of Open Access Journals: DOAJ Articles |
مصطلحات موضوعية: | multiple sclerosis, HOG cells, oligodendrocyte precursor cells, oligodendrocytes, corticosteroids, demyelination, Cytology, QH573-671 |
الوصف: | The implantation of oligodendrocyte precursor cells may be a useful therapeutic strategy for targeting remyelination. However, it is yet to be established how these cells behave after implantation and whether they retain the capacity to proliferate or differentiate into myelin-forming oligodendrocytes. One essential issue is the creation of administration protocols and determining which factors need to be well established. There is controversy around whether these cells may be implanted simultaneously with corticosteroid treatment, which is widely used in many clinical situations. This study assesses the influence of corticosteroids on the capacity for proliferation and differentiation and the survival of human oligodendroglioma cells. Our findings show that corticosteroids reduce the capacity of these cells to proliferate and to differentiate into oligodendrocytes and decrease cell survival. Thus, their effect does not favour remyelination; this is consistent with the results of studies with rodent cells. In conclusion, protocols for the administration of oligodendrocyte lineage cells with the aim of repopulating oligodendroglial niches or repairing demyelinated axons should not include corticosteroids, given the evidence that the effects of these drugs may undermine the objectives of cell transplantation. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
تدمد: | 2073-4409 |
العلاقة: | https://www.mdpi.com/2073-4409/12/11/1515Test; https://doaj.org/toc/2073-4409Test; https://doaj.org/article/68b49f85671e47a0bb366570e91442d3Test |
DOI: | 10.3390/cells12111515 |
الإتاحة: | https://doi.org/10.3390/cells12111515Test https://doaj.org/article/68b49f85671e47a0bb366570e91442d3Test |
رقم الانضمام: | edsbas.3003A94B |
قاعدة البيانات: | BASE |
تدمد: | 20734409 |
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DOI: | 10.3390/cells12111515 |