Decreased Cerebrospinal Fluid Antioxidative Capacity Is Related to Disease Severity and Progression in Early Multiple Sclerosis
| العنوان: | Decreased Cerebrospinal Fluid Antioxidative Capacity Is Related to Disease Severity and Progression in Early Multiple Sclerosis |
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| المؤلفون: | Daniela Pinter, Margarete M Voortman, Anna Damulina, Gerhard Bachmaier, Michael Khalil, Alexander Pichler, Lukas Pirpamer, Christian Enzinger, J.J. Archelos, Stefan Ropele, Gunther Marsche |
| المصدر: | Biomolecules, Vol 11, Iss 1264, p 1264 (2021) Biomolecules Volume 11 Issue 9 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, antioxidant activity, multiple sclerosis, Biochemistry, Gastroenterology, Severity of Illness Index, Microbiology, Antioxidants, Article, cerebrospinal fluid, Disability Evaluation, Cerebrospinal fluid, Disease severity, Neuronal damage, Internal medicine, medicine, Humans, magnetic resonance imaging, Subclinical disease, Molecular Biology, Clinically isolated syndrome, medicine.diagnostic_test, business.industry, Multiple sclerosis, Magnetic resonance imaging, Clinical disease, medicine.disease, QR1-502, Case-Control Studies, Disease Progression, Female, business, serum, Follow-Up Studies |
| الوصف: | Background: Oxidative stress-induced neuronal damage in multiple sclerosis (MS) results from an imbalance between toxic free radicals and counteracting antioxidants, i.e., antioxidative capacity (AOC). The relation of AOC to outcome measures in MS still remains inconclusive. We aimed to compare AOC in cerebrospinal fluid (CSF) and serum between early MS and controls and assess its correlation with clinical/radiological measures. Methods: We determined AOC (ability of CSF and serum of patients to inhibit 2,2′-azobis(2-amidinopropane) dihydrochloride-induced oxidation of dihydrorhodamine) in clinically isolated syndrome (CIS)/early relapsing-remitting MS (RRMS) (n = 55/11) and non-inflammatory neurological controls (n = 67). MS patients underwent clinical follow-up (median, 4.5 IQR, 5.2 years) and brain MRI at 3 T (baseline/follow-up n = 47/34 median time interval, 3.5 IQR, 2.1 years) to determine subclinical disease activity. Results: CSF AOC was differently regulated among CIS, RRMS and controls (p = 0.031) and lower in RRMS vs. CIS (p = 0.020). Lower CSF AOC correlated with physical disability (r = −0.365, p = 0.004) and risk for future relapses (exp(β) = 0.929, p = 0.033). No correlations with MRI metrics were found. Conclusion: Decreased CSF AOC was associated with increased disability and clinical disease activity in MS. While our finding cannot prove causation, they should prompt further investigations into the role of AOC in the evolution of MS. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e094ba9cbcdd3f82a73b77f8af98b5f6Test https://www.mdpi.com/2218-273X/11/9/1264Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e094ba9cbcdd3f82a73b77f8af98b5f6 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |