Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress
| العنوان: | Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress |
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| المؤلفون: | Emilia Di Giovanni, Sonia Melino, Ilaria Cacciotti, Matteo Ciocci, Francesca Nanni |
| المصدر: | International Journal of Molecular Sciences, Vol 19, Iss 8, p 2368 (2018) International Journal of Molecular Sciences Volume 19 Issue 8 |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, 02 engineering and technology, Regenerative medicine, lcsh:Chemistry, Hydrogen Sulfide, lcsh:QH301-705.5, Spectroscopy, Aged, 80 and over, Chemistry, Biomaterial, General Medicine, Middle Aged, 021001 nanoscience & nanotechnology, Computer Science Applications, Membrane, PLA fibers, antibacterial properties, cytotoxicity, garlic extracts, mesenchymal stem cells, microstructure, organosulfur compounds, thermal and mechanical properties, Female, Stem cell, 0210 nano-technology, Cell signaling, Cell Survival, Settore ING-IND/22 - Scienza e Tecnologia dei Materiali, Context (language use), Article, Catalysis, Cell Line, Inorganic Chemistry, 03 medical and health sciences, Humans, Settore BIO/10, Physical and Theoretical Chemistry, Garlic, Molecular Biology, Aged, Cell Proliferation, Plant Extracts, Organic Chemistry, Mesenchymal stem cell, Membranes, Artificial, In vitro, Oxidative Stress, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Biophysics |
| الوصف: | The design of biomaterial platforms able to release bioactive molecules is mandatory in tissue repair and regenerative medicine. In this context, electrospinning is a user-friendly, versatile and low-cost technique, able to process different kinds of materials in micro- and nano-fibers with a large surface area-to-volume ratio for an optimal release of gaseous signaling molecules. Recently, the antioxidant and anti-inflammatory properties of the endogenous gasotramsmitter hydrogen sulfide (H2S), as well as its ability to stimulate relevant biochemical processes on the growth of mesenchymal stem cells (MSC), have been investigated. Therefore, in this work, new poly(lactic) acid fibrous membranes (PFM), doped and functionalized with H2S slow-releasing donors extracted from garlic, were synthetized. These innovative H2S-releasing mats were characterized for their morphological, thermal, mechanical, and biological properties. Their antimicrobial activity and effects on the in vitro human cardiac MSC growth, either in the presence or in the absence of oxidative stress, were here assessed. On the basis of the results here presented, these new H2S-releasing PFM could represent promising and low-cost scaffolds or patches for biomedical applications in tissue repair. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ed6df63f8afe0086c39cdf1348ffe7Test http://www.mdpi.com/1422-0067/19/8/2368Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....24ed6df63f8afe0086c39cdf1348ffe7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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