Laser Doppler Blood Flow Imaging Using a CMOS Imaging Sensor with On-Chip Signal Processing
| العنوان: | Laser Doppler Blood Flow Imaging Using a CMOS Imaging Sensor with On-Chip Signal Processing |
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| المؤلفون: | Geraldine F. Clough, Stephen P. Morgan, Cally Gill, H. C. Nguyen, Diwei He, Barrie Hayes-Gill, John A. Crowe, Yiqun Zhu |
| المصدر: | Sensors, Vol 13, Iss 9, Pp 12632-12647 (2013) Sensors (Basel, Switzerland) Sensors; Volume 13; Issue 9; Pages: 12632-12647 |
| بيانات النشر: | MDPI AG, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Engineering, imaging sensor, Transducers, Normalization (image processing), ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, laser Doppler, Analog signal processing, lcsh:Chemical technology, 01 natural sciences, Biochemistry, Signal, Sensitivity and Specificity, Article, Analytical Chemistry, 010309 optics, Sensor array, 0103 physical sciences, Electronic engineering, Laser-Doppler Flowmetry, Humans, blood flow, lcsh:TP1-1185, Electrical and Electronic Engineering, Image sensor, Instrumentation, Signal processing, Blood Volume Determination, CMOS, full field, business.industry, 010401 analytical chemistry, Detector, Reproducibility of Results, Signal Processing, Computer-Assisted, Filter (signal processing), Equipment Design, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, Equipment Failure Analysis, Semiconductors, business, Blood Flow Velocity |
| الوصف: | The first fully integrated 2D CMOS imaging sensor with on-chip signal processing for applications in laser Doppler blood flow (LDBF) imaging has been designed and tested. To obtain a space efficient design over 64 × 64 pixels means that standard processing electronics used off-chip cannot be implemented. Therefore the analog signal processing at each pixel is a tailored design for LDBF signals with balanced optimization for signal-to-noise ratio and silicon area. This custom made sensor offers key advantages over conventional sensors, viz. the analog signal processing at the pixel level carries out signal normalization; the AC amplification in combination with an anti-aliasing filter allows analog-to-digital conversion with a low number of bits; low resource implementation of the digital processor enables on-chip processing and the data bottleneck that exists between the detector and processing electronics has been overcome. The sensor demonstrates good agreement with simulation at each design stage. The measured optical performance of the sensor is demonstrated using modulated light signals and in vivo blood flow experiments. Images showing blood flow changes with arterial occlusion and an inflammatory response to a histamine skin-prick demonstrate that the sensor array is capable of detecting blood flow signals from tissue. |
| وصف الملف: | application/pdf; PDF |
| اللغة: | English |
| تدمد: | 1424-8220 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2cb1a57b12a7420f5e142bfd2a2d0aTest http://www.mdpi.com/1424-8220/13/9/12632Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0e2cb1a57b12a7420f5e142bfd2a2d0a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14248220 |
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