دورية أكاديمية
Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System
| العنوان: | Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System |
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| المؤلفون: | Ulises Gómez-Pinedo, Yolanda García-Ávila, Lucía Gallego-Villarejo, Jordi A. Matías-Guiu, María Soledad Benito-Martín, Noelia Esteban-García, Inmaculada Sanclemente-Alamán, Vanesa Pytel, Lidia Moreno-Jiménez, Francisco Sancho-Bielsa, Lucía Vidorreta-Ballesteros, Paloma Montero-Escribano, Jorge Matías-Guiu |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 5192, p 5192 (2021) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | AQP4–IgG, neurogenesis, neural stem cells, neuromyelitis optica, NMOSD, precursor cells, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Introduction: AQP4 (aquaporin-4)–immunoglobulin G (IgG)-mediated neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that affects the central nervous system, particularly the spinal cord and optic nerve; remyelination capacity in neuromyelitis optica is yet to be determined, as is the role of AQP4–IgG in cell differentiation. Material and Methods: We included three groups—a group of patients with AQP4–IgG-positive neuromyelitis optica, a healthy group, and a sham group. We analyzed differentiation capacity in cultures of neurospheres from the subventricular zone of mice by adding serum at two different times: early and advanced stages of differentiation. We also analyzed differentiation into different cell lines. Results and Conclusions: The effect of sera from patients with NMOSD on precursor cells differs according to the degree of differentiation, and probably affects oligodendrocyte progenitor cells from NG2 cells to a lesser extent than cells from the subventricular zone; however, the resulting oligodendrocytes may be compromised in terms of maturation and possibly limited in their ability to generate myelin. Furthermore, these cells decrease in number with age. It is very unlikely that the use of drugs favoring the migration and differentiation of oligodendrocyte progenitor cells in multiple sclerosis would be effective in the context of neuromyelitis optica, but cell therapy with oligodendrocyte progenitor cells seems to be a potential alternative. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/22/10/5192Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test; https://doaj.org/article/952e259f88ee49c1a2d4f8c7b87e1ea1Test |
| DOI: | 10.3390/ijms22105192 |
| الإتاحة: | https://doi.org/10.3390/ijms22105192Test https://doaj.org/article/952e259f88ee49c1a2d4f8c7b87e1ea1Test |
| رقم الانضمام: | edsbas.8A3F3700 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms22105192 |